@article{oai:repo.qst.go.jp:00046091, author = {Hirayama, Ryoichi and Uzawa, Akiko and Matsumoto, Yoshitaka and Noguchi, Miho and Kase, Yuki and Takase, Nobuhiro and Ito, Atsushi and Koike, Sachiko and Ando, Koichi and Okayasu, Ryuichi and Furusawa, Yoshiya and 平山 亮一 and 鵜澤 玲子 and 松本 孔貴 and 伊藤 敦 and 小池 幸子 and 岡安 隆一 and 古澤 佳也}, issue = {2-4}, journal = {Radiation Protection Dosimetry}, month = {Feb}, note = {We studied DSB induction and rejoining in the clamped and non-clamped transplanted tumors in mice leg after 80 keV/µm carbon ions and X-rays. The yields of DSB in the tumors were analyzed by a static-field gel electrophoresis. The OER of DSB after X-rays was 1.68 +/- 0.31, and this value was not changed by one hour rejoining time (1.40 +/- 0.26). These damages in oxygenated conditions were rejoined 60 to 70% within one hour in situ. On the other hand, no difference between X-rays and carbon ions was found for the induction and rejoining of DSB. Thus, the values of OER and rejoined fraction after carbon ions were similar to that after X-rays, and the calculated RBEs of carbon ion were around 1 under both oxygen conditions. The yields of DSB in vivo depend on exposure doses, oxygen conditions and rejoining time, but not the types of radiation quality.}, pages = {508--512}, title = {INDUCTION OF DNA DSB AND ITS REJOINING IN CLAMPED AND NON-CLAMPED TUMOURS AFTER EXPOSURE TO CARBON ION BEAMS IN COMPARISON TO X RAYS}, volume = {143}, year = {2011} }