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Effects of Low-dose Heavy Ions on the Postnatal Development of Mice and the Yield of White Spots in the Mid-ventrum and Tail-tips
https://repo.qst.go.jp/records/46087
https://repo.qst.go.jp/records/46087d77ec390-add5-4007-9457-06b800638468
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-06-02 | |||||
| タイトル | ||||||
| タイトル | Effects of Low-dose Heavy Ions on the Postnatal Development of Mice and the Yield of White Spots in the Mid-ventrum and Tail-tips | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× Eguchi-Kasai, Kiyomi× Sugaya, Kimihiko× Murakami, Masahiro× 廣部 知久× 笠井 清美× 菅谷 公彦× 村上 正弘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Effects of prenatal low-dose irradiations of heavy ions on the postnatal development of mice and of melanocytes have not been well studied. Pregnant females of C57BL/10J mice were irradiated whole-body at 9 days of gestation with a single acute dose of gamma-rays, silicon (Si), argon (Ar) and iron (Fe) ions. The effects were studied by scoring changes in the postnatal development of mice as well as in the pigmentation of cutaneous coats and tail-tips of their offspring 22 days after birth. The survival to day 22 decreased from the offspring exposed to 0.4 Gy of argon and iron ions and to 0.75 Gy of silicon ions. White spots were found in the mid-ventrum and tail-tips of irradiated offspring. The frequency and size of the white spots in the mid-ventrum in mice exposed to silicon, argon and iron ions were greater than those of gamma-rays. Even in the low dose (0.1 Gy), gamma-rays and heavy ions increased the frequency of the ventral spots. The RBE estimated by the frequency of the ventral spots was 2.3 (Si), 3.1 (Ar) and 4.5 (Fe). These results suggest that prenatal exposure to heavy ions possesses a greater effect on the postnatal development of mice as well as melanocyte development than does exposure to gamma-rays. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 52, 号 3, p. 278-286, 発行日 2011-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1269/jrr.10140 | |||||
