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Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model
https://repo.qst.go.jp/records/46078
https://repo.qst.go.jp/records/460785bf8ac1d-6010-4895-80a2-236d33dfbccd
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-24 | |||||
| タイトル | ||||||
| タイトル | Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Inaniwa, Taku
× Inaniwa, Taku× Furukawa, Takuji× Kase, Yuuki× Matsufuji, Naruhiro× Toshitou, Toshiyuki× Matsumoto, Yoshitaka× Furusawa, Yoshiya× Noda, Kouji× 稲庭 拓× 古川 卓司× 加瀬 優紀× 松藤 成弘× 歳藤 利行× 松本 孔貴× 古澤 佳也× 野田 耕司 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We describe a method to calculate the relative biological effectiveness in mixed radiation fields of therapeutic ion beams based on the modified microdosimetric kinetic model (modified MKM). In addition, we show the procedure for integrating the modified MKM into a treatment planning system for a scanned carbon beam. With this procedure, the model is fully integrated into our research version of the treatment planning system. To account for the change in radiosensitivity of a cell line, we measured one of the three MKM parameters from a single survival curve of the current cells and used the parameter in biological optimization. Irradiation of human salivary gland tumor cells was performed with a scanned carbon beam in the Heavy Ion Medical Accelerator in Chiba (HIMAC), and we then compared the measured depth-survival curve with the modified MKM predicted survival curve. Good agreement between the two curves proves that the proposed method is a candidate for calculating the biological effects in treatment planning for ion irradiation. | |||||
| 書誌情報 |
Physics in Medicine and Biology 巻 55, 号 22, p. 6721-6737, 発行日 2010-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/0031-9155/55/22/008 | |||||
