@article{oai:repo.qst.go.jp:00046078,
 author = {Inaniwa, Taku and Furukawa, Takuji and Kase, Yuuki and Matsufuji, Naruhiro and Toshitou, Toshiyuki and Matsumoto, Yoshitaka and Furusawa, Yoshiya and Noda, Kouji and 稲庭 拓 and 古川 卓司 and 加瀬 優紀 and 松藤 成弘 and 歳藤 利行 and 松本 孔貴 and 古澤 佳也 and 野田 耕司},
 issue = {22},
 journal = {Physics in Medicine and Biology},
 month = {Oct},
 note = {We describe a method to calculate the relative biological effectiveness in mixed radiation fields of therapeutic ion beams based on the modified microdosimetric kinetic model (modified MKM). In addition, we show the procedure for integrating the modified MKM into a treatment planning system for a scanned carbon beam. With this procedure, the model is fully integrated into our research version of the treatment planning system. To account for the change in radiosensitivity of a cell line, we measured one of the three MKM parameters from a single survival curve of the current cells and used the parameter in biological optimization. Irradiation of human salivary gland tumor cells was performed with a scanned carbon beam in the Heavy Ion Medical Accelerator in Chiba (HIMAC), and we then compared the measured depth-survival curve with the modified MKM predicted survival curve. Good agreement between the two curves proves that the proposed method is a candidate for calculating the biological effects in treatment planning for ion irradiation.},
 pages = {6721--6737},
 title = {Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model},
 volume = {55},
 year = {2010}
}