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BRCA1 involves in regulation of Bcl-2 expression and apoptosis susceptibility to ionizing radiation
https://repo.qst.go.jp/records/46070
https://repo.qst.go.jp/records/460705b4bbf76-ef5e-4a29-a88c-2f87a3cbfdd1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-23 | |||||
| タイトル | ||||||
| タイトル | BRCA1 involves in regulation of Bcl-2 expression and apoptosis susceptibility to ionizing radiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wang, Yanling
× Wang, Yanling× Bing, Wang× Zhang, Hong× Li, Ning× Tanaka, Kaoru× Zhou, Xin× Chen, Ruping× Zhang, Xin× 王 冰× 田中 薫× Ｚｈａｎｇ Ｘｉｎ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BRCA1 has been proposed to be tightly linked to the resistance of tumor cells to ionizing radiation. The pathway leading to this phenomenon is not yet clear. In this work, we investigated the role of BRCA1 in the apoptosis regulation in response to carbon ion irradiation. We utilized three different cancer cell lines with various states for BRCA1 and p53 to identify the relationship between endogenous BRCA1 and the apoptosis-related genes, and determine whether p53 function would affect the role of BRCA1 in apoptosis regulation. By Western blot analysis, we found that Bax expressions were not significantly changed after irradiation in all of three cell lines. However, Bcl-2 expression showed an up-regulation by endogenous BRCA1 regardless of p53 status. Moreover, the changes in Bcl-2 protein were due to the increase in the transcriptional levels of Bcl-2 mRNA, based on real-time PCR assay. At the same time, BRCA1-deficient cells appeared a greater apoptosis susceptibility to irradiation when compared with BRCA1-proficient cells. The results suggest that BRCA1 might exert p53-independent regulative activities for Bcl-2, which seems account for the low apoptosis susceptibility in BRCA1-proficient carcinomas. |
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| 書誌情報 |
Science China Physics, Mechanics and Astronomy 巻 54, 号 5, p. 916-922, 発行日 2011-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1674-7348 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s11433-011-4264-6 | |||||
