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Uptake Decrease of Proliferative PET Tracer 18FLT in Bone Marrow after Carbon Ion Therapy in Lung Cancer
https://repo.qst.go.jp/records/46053
https://repo.qst.go.jp/records/4605300a6f051-3a57-4711-af75-4bd8784da899
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-23 | |||||
| タイトル | ||||||
| タイトル | Uptake Decrease of Proliferative PET Tracer 18FLT in Bone Marrow after Carbon Ion Therapy in Lung Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Koizumi, Mitsuru
× Koizumi, Mitsuru× Saga, Tsuneo× Inubushi, Masayuki× Fukumura, Toshimitsu× Yoshikawa, Kyosan× Yamamoto, Naoyoshi× Nakajima, Mio× Sugane, Toshio× Baba, Masayuki× 小泉 満× 佐賀 恒夫× 犬伏 正幸× 福村 利光× 吉川 京燦× 山本 直敬× 中嶋 美緒× 須金 紀雄× 馬場 雅行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose The aim of this study was to investigate the change of 3'-[18F]fluoro-3'-deoxy-l-thymidine (18FLT) uptake in normal bone marrow (BM) after inevitable radiation. Procedures Twenty-one non-small cell lung cancer patients who received carbon ion radiotherapy (CIRT) were studied with 18FLT-positron emission tomography/computed tomography (PET/CT) at pre- and post-CIRT. Radiation dose was calculated by radiation planning. Irradiated BM was divided into three groups (<10% of maximum dose, 10-30%, and >30%). Results 18FLT uptake clearly decreased at >10% irradiated areas and mildly decreased at <10% areas. 18FLT uptake was lowest just after CIRT, somewhat increased at 3 months, and remained unchanged for more than 1 year. There was no significant difference between 10-30% and >30% areas. Conclusion 18FLT revealed that BM function decreased by small dose such as <4.2-4.4 GyE/1 fraction of CIRT and is eradicated by >4.2-4.4 GyE/1 fraction. |
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| 書誌情報 |
Molecular Imaging and Biology 巻 13, 号 3, p. 577-582, 発行日 2010-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1536-1632 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s11307-010-0363-4 | |||||
