@article{oai:repo.qst.go.jp:00046053,
 author = {Koizumi, Mitsuru and Saga, Tsuneo and Inubushi, Masayuki and Fukumura, Toshimitsu and Yoshikawa, Kyosan and Yamamoto, Naoyoshi and Nakajima, Mio and Sugane, Toshio and Baba, Masayuki and 小泉 満 and 佐賀 恒夫 and 犬伏 正幸 and 福村 利光 and 吉川 京燦 and 山本 直敬 and 中嶋 美緒 and 須金 紀雄 and 馬場 雅行},
 issue = {3},
 journal = {Molecular Imaging and Biology},
 month = {Jun},
 note = {Purpose  
The aim of this study was to investigate the change of 3'-[18F]fluoro-3'-deoxy-l-thymidine (18FLT) uptake in normal bone marrow (BM) after inevitable radiation. 
Procedures  
Twenty-one non-small cell lung cancer patients who received carbon ion radiotherapy (CIRT) were studied with 18FLT-positron emission tomography/computed tomography (PET/CT) at pre- and post-CIRT. Radiation dose was calculated by radiation planning. Irradiated BM was divided into three groups (<10% of maximum dose, 10-30%, and >30%). 
Results  
18FLT uptake clearly decreased at >10% irradiated areas and mildly decreased at <10% areas. 18FLT uptake was lowest just after CIRT, somewhat increased at 3 months, and remained unchanged for more than 1 year. There was no significant difference between 10-30% and >30% areas. 
Conclusion  
18FLT revealed that BM function decreased by small dose such as <4.2-4.4 GyE/1 fraction of CIRT and is eradicated by >4.2-4.4 GyE/1 fraction.},
 pages = {577--582},
 title = {Uptake Decrease of Proliferative PET Tracer 18FLT in Bone Marrow after Carbon Ion Therapy in Lung Cancer},
 volume = {13},
 year = {2010}
}