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Nitroaldol reaction of nitro[11C]methane to form 2-(hydroxymethyl)-2-nitro[2-11C]-propane-1,3-diol and [11C]Tris
https://repo.qst.go.jp/records/46018
https://repo.qst.go.jp/records/4601824085947-7232-4407-a249-234bf7b780e5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-03-25 | |||||
| タイトル | ||||||
| タイトル | Nitroaldol reaction of nitro[11C]methane to form 2-(hydroxymethyl)-2-nitro[2-11C]-propane-1,3-diol and [11C]Tris | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kato, Koichi
× Kato, Koichi× Zhang, Ming-Rong× Minegishi, Katsuyuki× Nengaki, Nobuki× Takei, Makoto× Suzuki, Kazutoshi× 加藤 孝一× 張 明栄× 峯岸 克行× 念垣 信樹× 武井 誠× 鈴木 和年 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The nitroaldol reaction of nitro[11C]methane and formaldehyde, which yields 2-(hydroxymethyl)-2-nitro[2-11C]propane-1,3-diol, is explored. The fluoride-ion-assisted nitroaldol reaction using (C4H9)4NF was rapid and provided the desired nitrotriol in more than 97% radiochemical conversion (decay-corrected) in 3 min at room temperature. Neither 2-nitro[2-11C]ethanol nor 2-nitro[2-11C]propane-1,3-diol was observed under the reaction conditions. The preparation of 2-amino-2-(hydroxymethyl)-[2-11C]propane-1,3-diol ([11C]Tris) was described, which was followed by the nitro-group reduction using NiCl2 and NaBH4 in aqueous MeOH. The decay-corrected radiochemical conversion to [11C]Tris was 68.0+/-6.5% in two steps. | |||||
| 書誌情報 |
Journal of Labelled Compounds & Radiopharmaceuticals 巻 54, 号 3, p. 140-144, 発行日 2011-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0362-4803 | |||||
