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Fully automated synthesis of 13N-labeled nitrosothiols
https://repo.qst.go.jp/records/45904
https://repo.qst.go.jp/records/459047e115f7f-df70-4442-91c7-f286a397c8f9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-10-18 | |||||
| タイトル | ||||||
| タイトル | Fully automated synthesis of 13N-labeled nitrosothiols | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Gomez, Vanessa
× Gomez, Vanessa× Kato, Koichi× Llop, Jordi× et.al× Ｇｏｍｅｚ Ｖａｎｅｓｓａ× 加藤 孝一× Ｌｌｏｐ Ｊｏｒｄｉ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the present Letter, a fast, automated, and reproducible method for the synthesis of S-[13N]nitrosothiols is reported. The labeling strategy is based on trapping in an anion exchange resin. The reaction with thiols in acidic media led to the formation of the desired nitrosothiols in short reaction times (60 s) with excellent radiochemical conversions (from 48.7% to 74.5%). Final radiotracers were purified by HPLC. Good radiochemical yields (from 33.8% to 60.6%, decay corrected) and radiochemical purities (>99%) were obtained in all cases. Stability of the labeled compounds was checked. | |||||
| 書誌情報 |
Tetrahedron Letters 巻 51, 号 22, p. 2990-2993, 発行日 2010-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0040-4039 | |||||
