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Biological effects of low-dose ionizing radiation exposure on interventional cardiologists
https://repo.qst.go.jp/records/45899
https://repo.qst.go.jp/records/458992f459de3-3bd6-4d92-9257-67007216aaa5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-09-28 | |||||
| タイトル | ||||||
| タイトル | Biological effects of low-dose ionizing radiation exposure on interventional cardiologists | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zakeri, Farideh
× Zakeri, Farideh× Hirobe, Tomohisa× Akbari, Noghabi Kambiz× 廣部 知久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background Interventional cardiologists (ICs) are likely to receive high radiation exposure as a result of procedures they undertake. Aims To assess the effects of low-dose X-ray radiation exposure on chromosomal damage and on selected indices of cellular and humoral immunity in ICs. Methods The study population consisted of 37 ICs and 37 clinical physicians as the control group with similar age, sex and duration of employment, without any work-related exposure to ionizing radiation. Cytogenetic studies were performed by chromosome aberration analysis and immunological studies by flow cytometry, enzyme-linked immunosorbent assay and immunodiffusion techniques. Results The frequencies of aberrant cells, chromosome breaks and dicentrics plus centric rings were significantly higher in the exposed group compared to the control group (P , 0.05; P , 0.01; P , 0.001, respectively), without positive correlation between the frequency of dicentric and centric ring aberrations and the cumulative doses of the ICs (r 5 0.24, not significant). A significant increase was observed in the expression of activation marker CD69 on TCD41 stimulated cells in serum immunoglobulin G and interleukin (IL)-2 (P , 0.05) and a significant decrease in serum IL-10 (P , 0.05) in the ICs compared with that of the control group. There was no statistical difference between the two groups in terms of number of white blood cells and lymphocytes, CD31, CD41 and CD81 T cells, CD191 and CD161 561 cells and concentrations of interferon (IFN)-g, IL-4, IL-6 and IL-8 cytokines. Conclusions While cytogenetic results show higher chromosomal damage, some immune responses are stimulated or modulated immunologically in ICs. |
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| 書誌情報 |
Occupational Medicine 巻 60, 号 6, p. 464-469, 発行日 2010-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0962-7480 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/occmed/kqq062 | |||||
