@article{oai:repo.qst.go.jp:00045899,
 author = {Zakeri, Farideh and Hirobe, Tomohisa and Akbari, Noghabi Kambiz and 廣部 知久},
 issue = {6},
 journal = {Occupational Medicine},
 month = {Jun},
 note = {Background Interventional cardiologists (ICs) are likely to receive high radiation exposure as a result of procedures they undertake.
Aims To assess the effects of low-dose X-ray radiation exposure on chromosomal damage and on selected
indices of cellular and humoral immunity in ICs.
Methods The study population consisted of 37 ICs and 37 clinical physicians as the control group with similar
age, sex and duration of employment, without any work-related exposure to ionizing radiation. Cytogenetic
studies were performed by chromosome aberration analysis and immunological studies by
flow cytometry, enzyme-linked immunosorbent assay and immunodiffusion techniques.
Results The frequencies of aberrant cells, chromosome breaks and dicentrics plus centric rings were significantly higher in the exposed group compared to the control group (P , 0.05; P , 0.01; P , 0.001,
respectively), without positive correlation between the frequency of dicentric and centric ring aberrations
and the cumulative doses of the ICs (r 5 0.24, not significant). A significant increase was observed
in the expression of activation marker CD69 on TCD41 stimulated cells in serum immunoglobulin G and interleukin (IL)-2 (P , 0.05) and a significant decrease in serum IL-10 (P , 0.05) in the ICs compared with that of the control group. There was no statistical difference between the two groups in terms of number of white blood cells and lymphocytes, CD31, CD41 and CD81 T cells, CD191 and CD161 561 cells and concentrations of interferon (IFN)-g, IL-4, IL-6 and IL-8 cytokines.
Conclusions While cytogenetic results show higher chromosomal damage, some immune responses are stimulated or modulated immunologically in ICs.},
 pages = {464--469},
 title = {Biological effects of low-dose ionizing radiation exposure on interventional cardiologists},
 volume = {60},
 year = {2010}
}