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Chromosomal Aberrations Caused by Cu K-shell Ionization in Hypoxic Cells Containing Cu-ATSM
https://repo.qst.go.jp/records/45878
https://repo.qst.go.jp/records/458784da664f7-a177-4d9c-97da-318914cde05b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-08-05 | |||||
| タイトル | ||||||
| タイトル | Chromosomal Aberrations Caused by Cu K-shell Ionization in Hypoxic Cells Containing Cu-ATSM | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sinmi, Ayaka
× Sinmi, Ayaka× Kaji, Yoshirou× Kobayashi, Katsumi× Usami, Noriko× Maeda, Munetoshi× Fujibayashi, Yasuhisa× Furukawa, Takako× Yukawa, Masae× Iso, Hiroyuki× Ishikawa, Takahiro× Takakura, Kaoru× 新見 文香× 小林 克己× 宇佐美 徳子× 古川 高子× 湯川 雅枝× 磯 浩之× 石川 剛弘× 高倉 かほる |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The enhancement effect on chromosomal aberrations via selective X-ray energy absorption by Cu atoms in GM05389 normal fibroblast cells containing non-labeled copper(II)-diacetyl-bis(N4-methyl- thiosemicarbazone)(Cu-ATSM) was examined. The amounts of Cu-ATSM taken into cells were detected by PIXE analysis, and it was clarified that the amount of Cu atoms taken into hypoxic cells was about 2 or 3-times higher compared to that into normoxic cells. Radioisotope analysis with 64Cu-ATSM showed that 8.7% of all Cu atoms taken into a whole cell was distributed to the nucleus, and the remaining atoms to the cytoplasm in the cells. Irradiation with monochromatic X rays (CuK-H X rays) having an energy just above the Cu K-shell absorption edge on the hypoxic cells induced high yield of chromosomal aberrations, compared to that with X rays (CuK-L X rays) having an energy just below the Cu K-shell absorption edge. Enhanced chromosomal aberrations caused by Cu K-shell ionization or excitation was clearly observed in this study. | |||||
| 書誌情報 |
Metal Ions in Biology and Medicine 巻 10, p. 297-303, 発行日 2008 |
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