@article{oai:repo.qst.go.jp:00045878,
 author = {Sinmi, Ayaka and Kaji, Yoshirou and Kobayashi, Katsumi and Usami, Noriko and Maeda, Munetoshi and Fujibayashi, Yasuhisa and Furukawa, Takako and Yukawa, Masae and Iso, Hiroyuki and Ishikawa, Takahiro and Takakura, Kaoru and 新見 文香 and 小林 克己 and 宇佐美 徳子 and 古川 高子 and 湯川 雅枝 and 磯 浩之 and 石川 剛弘 and 高倉 かほる},
 journal = {Metal Ions in Biology and Medicine},
 month = {},
 note = {The enhancement effect on chromosomal aberrations via selective X-ray energy absorption by Cu atoms in GM05389 normal fibroblast cells containing non-labeled copper(II)-diacetyl-bis(N4-methyl- thiosemicarbazone)(Cu-ATSM) was examined. The amounts of Cu-ATSM taken into cells were detected by PIXE analysis, and it was clarified that the amount of Cu atoms taken into hypoxic cells was about 2 or 3-times higher compared to that into normoxic cells. Radioisotope analysis with 64Cu-ATSM showed that 8.7% of all Cu atoms taken into a whole cell was distributed to the nucleus, and the remaining atoms to the cytoplasm in the cells. Irradiation with monochromatic X rays (CuK-H X rays) having an energy just above the Cu K-shell absorption edge on the hypoxic cells induced high yield of chromosomal aberrations, compared to that with X rays (CuK-L X rays) having an energy just below the Cu K-shell absorption edge. Enhanced chromosomal aberrations caused by Cu K-shell ionization or excitation was clearly observed in this study.},
 pages = {297--303},
 title = {Chromosomal Aberrations Caused by Cu K-shell Ionization in Hypoxic Cells Containing Cu-ATSM},
 volume = {10},
 year = {2008}
}