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Adverse Effects of Androgen Deprivation Therapy on Persistent Genitourinary Complications after Carbon Ion Radiotherapy for Prostate Cancer
https://repo.qst.go.jp/records/45835
https://repo.qst.go.jp/records/4583589f653fd-39e7-4d5f-bc79-8d090c9ea3d1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-06-28 | |||||
| タイトル | ||||||
| タイトル | Adverse Effects of Androgen Deprivation Therapy on Persistent Genitourinary Complications after Carbon Ion Radiotherapy for Prostate Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishikawa, Hitoshi
× Ishikawa, Hitoshi× Tsuji, Hiroshi× Kamada, Tadashi× Hirasawa, Naoki× Yanagi, Takeshi× Mizoe, Junetsu× Akakura, Kouichirou× Shimazaki, Jun× Nakano, Takashi× Tsujii, Hirohiko× et.al× 石川 仁× 辻 比呂志× 鎌田 正× 平澤 直樹× 柳 剛× 溝江 純悦× 赤倉 功一郎× 島崎 淳× 中野 隆史× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE: To determine the risk factors for persistent late genitourinary (GU) morbidity after carbon ion radiotherapy (C-ion RT) for prostate cancer. METHODS AND MATERIALS: Between April 2000 and November 2003, a Phase II study of 175 prostate cancer patients was performed to assess C-ion RT with a dose fractionation (66 Gray equivalent in 20 fractions) established from previous Phase I-II studies. The effects of the clinical and dosimetric parameters on the occurrence of persistent GU toxicity in 172 patients who survived for >18 months after C-ion RT were examined retrospectively. C-ion RT alone was performed for 33 low-risk patients, and 139 high-risk patients received C-ion RT combined with androgen deprivation therapy (ADT). RESULTS: Grade 1 and 2 persistent GU toxicities developed in 36 (21%) and 3 (2%) patients, respectively. The use of long-course ADT (>or=24 months) and acute GU toxicity were associated with the occurrence of persistent toxicity by multivariate analysis (p = 0.016 and p = 0.048, respectively), but short-course ADT (<24 months) had no effect on the development of toxicity (p = 0.35). The 5-year actuarial complication rate of 80 patients undergoing long-course ADT was 31.1%; the corresponding rate for the 92 patients who received no ADT or short-course ADT was 22.2%. CONCLUSION: Adverse effects with long-course ADT on persistent GU morbidity were observed in this study. Additional investigation is needed to identify suitable ADT administration according to risk groups, but long-course ADT should not be adopted for non-high-risk prostate cancer patients to reduce the GU toxicity rate with C-ion RT. | |||||
| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 72, 号 1, p. 78-84, 発行日 2008-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
