{"created":"2023-05-15T14:35:38.404207+00:00","id":45835,"links":{},"metadata":{"_buckets":{"deposit":"ac553184-93f0-459a-8148-8accd3f419eb"},"_deposit":{"created_by":1,"id":"45835","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45835"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045835","sets":["1"]},"author_link":["455824","455811","455822","455810","455813","455806","455820","455818","455805","455816","455821","455823","455807","455814","455815","455809","455804","455808","455812","455819","455817"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"84","bibliographicPageStart":"78","bibliographicVolumeNumber":"72","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Oncology Biology Physics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE: To determine the risk factors for persistent late genitourinary (GU) morbidity after carbon ion radiotherapy (C-ion RT) for prostate cancer. METHODS AND MATERIALS: Between April 2000 and November 2003, a Phase II study of 175 prostate cancer patients was performed to assess C-ion RT with a dose fractionation (66 Gray equivalent in 20 fractions) established from previous Phase I-II studies. The effects of the clinical and dosimetric parameters on the occurrence of persistent GU toxicity in 172 patients who survived for >18 months after C-ion RT were examined retrospectively. C-ion RT alone was performed for 33 low-risk patients, and 139 high-risk patients received C-ion RT combined with androgen deprivation therapy (ADT). RESULTS: Grade 1 and 2 persistent GU toxicities developed in 36 (21%) and 3 (2%) patients, respectively. The use of long-course ADT (>or=24 months) and acute GU toxicity were associated with the occurrence of persistent toxicity by multivariate analysis (p = 0.016 and p = 0.048, respectively), but short-course ADT (<24 months) had no effect on the development of toxicity (p = 0.35). The 5-year actuarial complication rate of 80 patients undergoing long-course ADT was 31.1%; the corresponding rate for the 92 patients who received no ADT or short-course ADT was 22.2%. CONCLUSION: Adverse effects with long-course ADT on persistent GU morbidity were observed in this study. Additional investigation is needed to identify suitable ADT administration according to risk groups, but long-course ADT should not be adopted for non-high-risk prostate cancer patients to reduce the GU toxicity rate with C-ion RT.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0360-3016","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishikawa, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"455804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"455805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"455806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirasawa, Naoki"}],"nameIdentifiers":[{"nameIdentifier":"455807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanagi, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"455808","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizoe, Junetsu"}],"nameIdentifiers":[{"nameIdentifier":"455809","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akakura, Kouichirou"}],"nameIdentifiers":[{"nameIdentifier":"455810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimazaki, Jun"}],"nameIdentifiers":[{"nameIdentifier":"455811","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"455812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"455813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"455814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 比呂志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平澤 直樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柳 剛","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"溝江 純悦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"赤倉 功一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島崎 淳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野 隆史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455824","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Adverse Effects of Androgen Deprivation Therapy on Persistent Genitourinary Complications after Carbon Ion Radiotherapy for Prostate Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Adverse Effects of Androgen Deprivation Therapy on Persistent Genitourinary Complications after Carbon Ion Radiotherapy for Prostate Cancer"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-06-28"},"publish_date":"2010-06-28","publish_status":"0","recid":"45835","relation_version_is_last":true,"title":["Adverse Effects of Androgen Deprivation Therapy on Persistent Genitourinary Complications after Carbon Ion Radiotherapy for Prostate Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:59:02.236380+00:00"}