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Ascorbic acid gives different protective effects in human cells exposed to X-rays and heavy ions
https://repo.qst.go.jp/records/45799
https://repo.qst.go.jp/records/457991d727c00-d198-4f34-b13a-aa39cd5c15c1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-05-31 | |||||
| タイトル | ||||||
| タイトル | Ascorbic acid gives different protective effects in human cells exposed to X-rays and heavy ions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujii, Yoshihiro
× Fujii, Yoshihiro× Kato, Takamitsu× Ueno, Akiko× Kubota, Nobuo× Fujimori, Akira× Okayasu, Ryuichi× 藤井 義大× 加藤 宝光× 上野 昭子× 窪田 宜夫× 藤森 亮× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We studied the effects and mechanisms of ascorbic acid as a radiation protector. Cell survival, repair of DNA double strand breaks (DSBs), and sister chromatid exchanges (SCEs) were examined in normal human fibroblasts irradiated with X-rays and heavy ions. Post irradiation treatment with 5 mM ascorbic acid for 24 hours in plateau phase (non-cycling) cells enhanced cell survival and DNA double strand break repair, and reduced SCEs after X-rays irradiation. On the other hand, only reduced SCEs were observed after heavy ion exposure such as to carbon ions. Judging from our data, it is possible that the radioprotective action of ascorbic acid would be effective in non-complex type DNA damage such as induced by X-rays. These findings provide new insight into the mechanism of DNA damage and repair produced by heavy ion irradiation. |
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| 書誌情報 |
Genetic Toxicology and Environmental Mutagenesis : A Section of Mutation Research 巻 699, 号 1/2, p. 58-61, 発行日 2010-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1383-5718 | |||||
