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Platinum nanoparticles: a promising material for future cancer therapy?
https://repo.qst.go.jp/records/45782
https://repo.qst.go.jp/records/457828b45037f-08a7-4212-99d9-7048db71a0d6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-04-13 | |||||
| タイトル | ||||||
| タイトル | Platinum nanoparticles: a promising material for future cancer therapy? | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Porcel, Erika
× Porcel, Erika× Liehn, Samuel× Remita, Hynd× Usami, Noriko× Kobayashi, Katsumi× Furusawa, Yoshiya× Le, Sech Claude× LACOMBE, Sandrine× 宇佐美 徳子× 小林 克己× 古澤 佳也× ルシェッ クロード× ＬＡＣＯＭＢＥ Ｓａｎｄｒｉｎｅ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recently, the use of gold nanoparticles as potential tumor selective radiosensitizers has been proposed as a breakthrough in radiotherapy. Experiments in living cells and in vivo have demonstrated the efficiency of the metal nanoparticles when combined with low energy x-ray radiations (below conventional 1 MeV Linac radiation). Further studies on DNA have been performed in order to better understand the fundamental processes of sensitization and to further improve the method. In this work, we propose a new strategy based on the combination of platinum nanoparticles with irradiation by fast ions effectively used in hadron therapy. It is observed in particular that nanoparticles enhance strongly lethal damage in DNA, with an efficiency factor close to 2 for double strand breaks. In order to disentangle the effect of the nano-design architecture, a comparison with the effects of dispersed metal atoms at the same concentration has been performed. It is thus shown that the sensitization in nanoparticles is enhanced due to auto-amplified electronic cascades inside the nanoparticles, which reinforces the energy deposition in the close vicinity of the metal. Finally, the combination of fast ion radiation (hadron therapy) with platinum nanoparticles should strongly improve cancer therapy protocols. |
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| 書誌情報 |
Nanotechnology 巻 21, 号 8, p. 085103, 発行日 2010-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0957-4484 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/0957-4484/21/8/085103 | |||||
