@article{oai:repo.qst.go.jp:00045782,
 author = {Porcel, Erika and Liehn, Samuel and Remita, Hynd and Usami, Noriko and Kobayashi, Katsumi and Furusawa, Yoshiya and Le, Sech Claude and LACOMBE, Sandrine and 宇佐美 徳子 and 小林 克己 and 古澤 佳也 and ルシェッ クロード and ＬＡＣＯＭＢＥ Ｓａｎｄｒｉｎｅ},
 issue = {8},
 journal = {Nanotechnology},
 month = {Jan},
 note = {Recently, the use of gold nanoparticles as potential tumor selective radiosensitizers has been proposed as a breakthrough in radiotherapy. Experiments in living cells and in vivo have demonstrated the efficiency of the metal nanoparticles when combined with low energy x-ray radiations (below conventional 1 MeV Linac radiation). Further studies on DNA have been performed in order to better understand the fundamental processes of sensitization and to further improve the method.
In this work, we propose a new strategy based on the combination of platinum nanoparticles with irradiation by fast ions effectively used in hadron therapy. It is observed in particular that nanoparticles enhance strongly lethal damage in DNA, with an efficiency factor close to 2 for double strand breaks. In order to disentangle the effect of the nano-design architecture, a comparison with the effects of dispersed metal atoms at the same concentration has been performed. It is thus shown that the sensitization in nanoparticles is enhanced due to auto-amplified electronic cascades inside the nanoparticles, which reinforces the energy deposition in the close vicinity of the metal. Finally, the combination of fast ion radiation (hadron therapy) with platinum nanoparticles should strongly improve cancer therapy protocols.},
 title = {Platinum nanoparticles: a promising material for future cancer therapy?},
 volume = {21},
 year = {2010}
}