Contribution of dopamine D1 and D2 receptors to amygdala activity in human

Several animal studies have demonstrated functional roles of dopamine (DA) D1 and D2 receptors in amygdala activity. However, the
contribution of DA D1 and D2 receptors to amygdala response induced by affective stimuli in human is unknown. To investigate the
contribution of DA receptor subtypes to amygdala reactivity in human, we conducted a multimodal in vivo neuroimaging study in which
DA D1 and D2 receptor bindings in the amygdala were measured with positron emission tomography (PET), and amygdala response
induced by fearful faces was assessed by functional magnetic resonance imaging (fMRI) in healthy volunteers. We used multimodality
voxelwise correlation analysis between fMRI signal and DA receptor binding measured by PET. DA D1 binding in the amygdala was
positively correlated with amygdala signal change in response to fearful faces, but DA D2 binding in the amygdala was not related to
amygdala signal change. DA D1 receptors might play a major role in enhancing amygdala response when sensory inputs are affective.

書誌情報

The Journal of Neuroscience

巻 30, 号 8, p. 3043-3047, 発行日 2010-02

ISSN

収録物識別子タイプ

ISSN

収録物識別子

0270-6474

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