@article{oai:repo.qst.go.jp:00045764, author = {Takahashi, Hidehiko and Takano, Harumasa and Kodaka, Fumitoshi and Arakawa, Ryosuke and Yamada, Makiko and Otsuka, Tatsui and Hirano, Yoshiyuki and Kikyo, Hideyuki and Okubo, Yoshiro and Kato, Motoichiro and Obata, Takayuki and Ito, Hiroshi and Suhara, Tetsuya and 高橋 英彦 and 高野 晴成 and 小高 文聰 and 荒川 亮介 and 山田 真希子 and 大塚 達以 and 平野 好幸 and 桔梗 英幸 and 大久保 善朗 and 加藤 元一郎 and 小畠 隆行 and 伊藤 浩 and 須原 哲也}, issue = {8}, journal = {The Journal of Neuroscience}, month = {Feb}, note = {Several animal studies have demonstrated functional roles of dopamine (DA) D1 and D2 receptors in amygdala activity. However, the contribution of DA D1 and D2 receptors to amygdala response induced by affective stimuli in human is unknown. To investigate the contribution of DA receptor subtypes to amygdala reactivity in human, we conducted a multimodal in vivo neuroimaging study in which DA D1 and D2 receptor bindings in the amygdala were measured with positron emission tomography (PET), and amygdala response induced by fearful faces was assessed by functional magnetic resonance imaging (fMRI) in healthy volunteers. We used multimodality voxelwise correlation analysis between fMRI signal and DA receptor binding measured by PET. DA D1 binding in the amygdala was positively correlated with amygdala signal change in response to fearful faces, but DA D2 binding in the amygdala was not related to amygdala signal change. DA D1 receptors might play a major role in enhancing amygdala response when sensory inputs are affective.}, pages = {3043--3047}, title = {Contribution of dopamine D1 and D2 receptors to amygdala activity in human}, volume = {30}, year = {2010} }