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Quality Control of PET Radiopharmaceuticals by High-Performance Liquid Chromatography with tris(2,2'-bipyridyl)ruthenium(II) Electrogenerated Chemiluminescence Detection.
https://repo.qst.go.jp/records/45743
https://repo.qst.go.jp/records/45743ef7cb136-a9c2-4b2b-b655-1578ffdafda6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-02-03 | |||||
| タイトル | ||||||
| タイトル | Quality Control of PET Radiopharmaceuticals by High-Performance Liquid Chromatography with tris(2,2'-bipyridyl)ruthenium(II) Electrogenerated Chemiluminescence Detection. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakao, Ryuji
× Nakao, Ryuji× Furutsuka, Kenji× Fukumura, Toshimitsu× Yamaguchi, Masatoshi× Suzuki, Kazutoshi× 中尾 隆士× 古塚 賢士× 福村 利光× 山口 政俊× 鈴木 和年 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A highly sensitive reversed-phase liquid chromatographic (HPLC) method was investigated to analyze a range of positron emission tomography (PET) radiopharmaceuticals using electrogenerated chemiluminescence (ECL) detection. ECL is based on the reaction of PET molecules with tris(2,2-bipyridyl)ruthenium(III) [Ru(bpy)33+], which is generated through the on-line electro-oxidation of Ru(bpy)32+. In 21 different radiopharmaceuticals studied, 18 compounds could be detected with detection limits (signal-to-noise ratio = 3) of 0.12-72 ng/mL per 20 L injection. Sufficient reproducibility and linearity were obtained for the quantitative determination of PET molecules in pharmaceutical fluid. This method could be successfully applied to quality control tests of PET radiopharmaceuticals with ultra-high specific radioactivity. | |||||
| 書誌情報 |
Biomedical Chromatography 巻 24, 号 2, p. 202-208, 発行日 2010-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0269-3879 | |||||
