@article{oai:repo.qst.go.jp:00045743,
 author = {Nakao, Ryuji and Furutsuka, Kenji and Fukumura, Toshimitsu and Yamaguchi, Masatoshi and Suzuki, Kazutoshi and 中尾 隆士 and 古塚 賢士 and 福村 利光 and 山口 政俊 and 鈴木 和年},
 issue = {2},
 journal = {Biomedical Chromatography},
 month = {Feb},
 note = {A highly sensitive reversed-phase liquid chromatographic (HPLC) method was investigated to analyze a range of positron emission tomography (PET) radiopharmaceuticals using electrogenerated chemiluminescence (ECL) detection. ECL is based on the reaction of PET molecules with tris(2,2-bipyridyl)ruthenium(III) [Ru(bpy)33+], which is generated through the on-line electro-oxidation of Ru(bpy)32+. In 21 different radiopharmaceuticals studied, 18 compounds could be detected with detection limits (signal-to-noise ratio = 3) of 0.12-72 ng/mL per 20 L injection. Sufficient reproducibility and linearity were obtained for the quantitative determination of PET molecules in pharmaceutical fluid. This method could be successfully applied to quality control tests of PET radiopharmaceuticals with ultra-high specific radioactivity.},
 pages = {202--208},
 title = {Quality Control of PET Radiopharmaceuticals by High-Performance Liquid Chromatography with tris(2,2'-bipyridyl)ruthenium(II) Electrogenerated Chemiluminescence Detection.},
 volume = {24},
 year = {2010}
}