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Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission?
https://repo.qst.go.jp/records/45730
https://repo.qst.go.jp/records/457306ff0446e-e500-4286-ad25-e18bc87dfed6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-01-19 | |||||
| タイトル | ||||||
| タイトル | Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission? | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ito, Hiroshi
× Ito, Hiroshi× Takano, Harumasa× Takahashi, Hidehiko× Arakawa, Ryosuke× Miyoshi, Michie× Kodaka, Fumitoshi× Okumura, Masaki× Otsuka, Tatsui× Suhara, Tetsuya× 伊藤 浩× 高野 晴成× 高橋 英彦× 荒川 亮介× 三好 美智恵× 小高 文聰× 奥村 正紀× 大塚 達以× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Effects of antipsychotic drugs have widely been considered to be mediated by blockade of dopamine D2 receptors. Effects of antipsychotics on presynaptic functions of dopaminergic neurotransmission might also be related to therapeutic effects of antipsychotics. To investigate the effects of antipsychotics on presynaptic functions of dopaminergic neurotransmission in relation with occupancy of dopamine D2 receptors, changes in dopamine synthesis rate by antipsychotics and occupancy of dopamine D2 receptors were measured by positron emission tomography (PET) in healthy men. PET studies using [11C]raclopride and L-[beta-11C]DOPA were performed under resting condition and oral administration of single dose of the antipsychotic drug risperidone on separate days. While occupancy of dopamine D2 receptors corresponding dose of risperidone was observed, the changes in dopamine synthesis rate by the administration of risperidone were not significant, nor was the relation between the occupancy of dopamine D2 receptors and these changes. A significant negative correlation was observed between the baseline dopamine synthesis rate and the changes in dopamine synthesis rate by risperidone, indicating that this antipsychotic can be assumed to stabilize the dopamine synthesis rate. The therapeutic effects of risperidone in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity. | |||||
| 書誌情報 |
The Journal of Neuroscience 巻 29, 号 43, p. 13730-13734, 発行日 2009-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0270-6474 | |||||
