@article{oai:repo.qst.go.jp:00045730,
 author = {Ito, Hiroshi and Takano, Harumasa and Takahashi, Hidehiko and Arakawa, Ryosuke and Miyoshi, Michie and Kodaka, Fumitoshi and Okumura, Masaki and Otsuka, Tatsui and Suhara, Tetsuya and 伊藤 浩 and 高野 晴成 and 高橋 英彦 and 荒川 亮介 and 三好 美智恵 and 小高 文聰 and 奥村 正紀 and 大塚 達以 and 須原 哲也},
 issue = {43},
 journal = {The Journal of Neuroscience},
 month = {Oct},
 note = {Effects of antipsychotic drugs have widely been considered to be mediated by blockade of dopamine D2 receptors. Effects of antipsychotics on presynaptic functions of dopaminergic neurotransmission might also be related to therapeutic effects of antipsychotics. To investigate the effects of antipsychotics on presynaptic functions of dopaminergic neurotransmission in relation with occupancy of dopamine D2 receptors, changes in dopamine synthesis rate by antipsychotics and occupancy of dopamine D2 receptors were measured by positron emission tomography (PET) in healthy men. PET studies using [11C]raclopride and L-[beta-11C]DOPA were performed under resting condition and oral administration of single dose of the antipsychotic drug risperidone on separate days. While occupancy of dopamine D2 receptors corresponding dose of risperidone was observed, the changes in dopamine synthesis rate by the administration of risperidone were not significant, nor was the relation between the occupancy of dopamine D2 receptors and these changes. A significant negative correlation was observed between the baseline dopamine synthesis rate and the changes in dopamine synthesis rate by risperidone, indicating that this antipsychotic can be assumed to stabilize the dopamine synthesis rate. The therapeutic effects of risperidone in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity.},
 pages = {13730--13734},
 title = {Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission?},
 volume = {29},
 year = {2009}
}