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  1. 原著論文

Significance of manipulating intratumor hypoxia in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent cells.

https://repo.qst.go.jp/records/45702
https://repo.qst.go.jp/records/45702
a1a34c27-021b-4b62-96a3-3ce04cd0a021
Item type 学術雑誌論文 / Journal Article(1)
公開日 2009-12-26
タイトル
タイトル Significance of manipulating intratumor hypoxia in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent cells.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Masunaga, Shinichiro

× Masunaga, Shinichiro

WEKO 454188

Masunaga, Shinichiro

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Matsumoto, Yoshitaka

× Matsumoto, Yoshitaka

WEKO 454189

Matsumoto, Yoshitaka

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Hirayama, Ryoichi

× Hirayama, Ryoichi

WEKO 454190

Hirayama, Ryoichi

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Kashino, Genro

× Kashino, Genro

WEKO 454191

Kashino, Genro

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Tanaka, Hiroki

× Tanaka, Hiroki

WEKO 454192

Tanaka, Hiroki

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Suzuki, Minoru

× Suzuki, Minoru

WEKO 454193

Suzuki, Minoru

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Kinashi, Yuko

× Kinashi, Yuko

WEKO 454194

Kinashi, Yuko

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Liu, Yong

× Liu, Yong

WEKO 454195

Liu, Yong

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Ando, Koichi

× Ando, Koichi

WEKO 454196

Ando, Koichi

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Ono, Koji

× Ono, Koji

WEKO 454197

Ono, Koji

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増永 慎一郎

× 増永 慎一郎

WEKO 454198

en 増永 慎一郎

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松本 孔貴

× 松本 孔貴

WEKO 454199

en 松本 孔貴

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平山 亮一

× 平山 亮一

WEKO 454200

en 平山 亮一

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田中 浩基

× 田中 浩基

WEKO 454201

en 田中 浩基

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小野 公二

× 小野 公二

WEKO 454202

en 小野 公二

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抄録
内容記述タイプ Abstract
内容記述 Purpose To evaluate the effect of manipulating intratumor hypoxia during radiotherapy on lung metastasis, referring to its effect on the sensitivity of quiescent tumor cells. Materials and Methods B16-BL6 melanoma tumor-bearing C57BL/6 mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. They received gamma-ray irradiation following loading with the acute hypoxia-releasing agent nicotinamide or local hyperthermia at mild temperatures (MTH). Immediately after the irradiation, cells from some tumors were isolated and incubated with a cytokinesis blocker. The sensitivity of quiescent (Q) cells was assessed in terms of the micronucleus frequency using immunofluorescence staining for BrdU. That of the total (=P + Q) tumor cell population was determined from BrdU non-treated tumors. In other tumor-bearing mice, 17 days after irradiation, macroscopic lung metastases were enumerated. Results In the total cells, a more marked enhancement in sensitivity was observed with nicotinamide than MTH. In Q cells, MTH combination induced a more marked enhancement than nicotinamide. Both nicotinamide and MTH reduced the size of the hypoxic fraction in the two cell populations, especially nicotinamide in the total cells and MTH in Q cells. Without gamma-ray irradiation, nicotinamide loading tended to decrease the number of lung metastases. With gamma-ray irradiation, nicotinamide loading and MTH, especially the former, reduced the number of metastases more than gamma-ray irradiation only. Conclusion Hypoxia manipulation in solid tumors has the potential to influence lung metastases. Notably, acute hypoxia-releasing nicotinamide may be promising for reducing the number of lung metastases.
書誌情報 Clinical & Experimental Metastasis

巻 26, 号 7, p. 693-700, 発行日 2009-05
ISSN
収録物識別子タイプ ISSN
収録物識別子 0262-0898
DOI
識別子タイプ DOI
関連識別子 10.1007/s10585-009-9268-5
関連サイト
識別子タイプ URI
関連識別子 http://www.springerlink.com/content/k4j1788551622t41/fulltext.pdf
関連名称 http://www.springerlink.com/content/k4j1788551622t41/fulltext.pdf
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