{"created":"2023-05-15T14:35:32.588252+00:00","id":45702,"links":{},"metadata":{"_buckets":{"deposit":"8944a1c3-0433-473c-8ccd-9f229c4cc739"},"_deposit":{"created_by":1,"id":"45702","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45702"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045702","sets":["1"]},"author_link":["454200","454198","454190","454202","454189","454201","454191","454195","454197","454199","454192","454188","454193","454196","454194"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"700","bibliographicPageStart":"693","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Clinical & Experimental Metastasis"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose To evaluate the effect of manipulating intratumor hypoxia during radiotherapy on lung metastasis, referring to its effect on the sensitivity of quiescent tumor cells. Materials and Methods B16-BL6 melanoma tumor-bearing C57BL/6 mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. They received gamma-ray irradiation following loading with the acute hypoxia-releasing agent nicotinamide or local hyperthermia at mild temperatures (MTH). Immediately after the irradiation, cells from some tumors were isolated and incubated with a cytokinesis blocker. The sensitivity of quiescent (Q) cells was assessed in terms of the micronucleus frequency using immunofluorescence staining for BrdU. That of the total (=P + Q) tumor cell population was determined from BrdU non-treated tumors. In other tumor-bearing mice, 17 days after irradiation, macroscopic lung metastases were enumerated. Results In the total cells, a more marked enhancement in sensitivity was observed with nicotinamide than MTH. In Q cells, MTH combination induced a more marked enhancement than nicotinamide. Both nicotinamide and MTH reduced the size of the hypoxic fraction in the two cell populations, especially nicotinamide in the total cells and MTH in Q cells. Without gamma-ray irradiation, nicotinamide loading tended to decrease the number of lung metastases. With gamma-ray irradiation, nicotinamide loading and MTH, especially the former, reduced the number of metastases more than gamma-ray irradiation only. Conclusion Hypoxia manipulation in solid tumors has the potential to influence lung metastases. Notably, acute hypoxia-releasing nicotinamide may be promising for reducing the number of lung metastases.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s10585-009-9268-5","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.springerlink.com/content/k4j1788551622t41/fulltext.pdf"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.springerlink.com/content/k4j1788551622t41/fulltext.pdf","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0262-0898","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Masunaga, Shinichiro"}],"nameIdentifiers":[{"nameIdentifier":"454188","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Yoshitaka"}],"nameIdentifiers":[{"nameIdentifier":"454189","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirayama, Ryoichi"}],"nameIdentifiers":[{"nameIdentifier":"454190","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kashino, Genro"}],"nameIdentifiers":[{"nameIdentifier":"454191","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"454192","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Minoru"}],"nameIdentifiers":[{"nameIdentifier":"454193","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kinashi, Yuko"}],"nameIdentifiers":[{"nameIdentifier":"454194","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Liu, Yong"}],"nameIdentifiers":[{"nameIdentifier":"454195","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"454196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Koji"}],"nameIdentifiers":[{"nameIdentifier":"454197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"増永 慎一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454198","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 孔貴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454199","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454200","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 浩基","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454201","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野 公二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454202","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Significance of manipulating intratumor hypoxia in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Significance of manipulating intratumor hypoxia in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent cells."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-12-26"},"publish_date":"2009-12-26","publish_status":"0","recid":"45702","relation_version_is_last":true,"title":["Significance of manipulating intratumor hypoxia in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent cells."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:00:39.678529+00:00"}