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11C-Methionine-PET for Evaluation of Carbon Ion Radiotherapy in Patients with Pelvic Recurrence of Rectal Cancer
https://repo.qst.go.jp/records/45492
https://repo.qst.go.jp/records/45492bc82f763-b82c-4dbb-84b0-12066e21c941
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-04-21 | |||||
| タイトル | ||||||
| タイトル | 11C-Methionine-PET for Evaluation of Carbon Ion Radiotherapy in Patients with Pelvic Recurrence of Rectal Cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Koizumi, Mitsuru
× Koizumi, Mitsuru× Saga, Tsuneo× Yoshikawa, Kyosan× Suzuki, Kazutoshi× Yamada, Shigeru× Hasebe, Mitsuhiko× Ohashi, Seiya× Mahmoud, Abd-Elrazek Helmy Sherif× Ishikawa, Hiroyuki× Sagou, Kenji× Hara, Ryusuke× Katou, Hirotoshi× Yasuda, Shigeo× Yanagi, Takeshi× Tsujii, Hirohiko× et.al× 小泉 満× 佐賀 恒夫× 吉川 京燦× 鈴木 和年× 山田 滋× 長谷部 充彦× 大橋 靖也× Ｓｈｅｒｉｆ Ｍａｈｍｏｕｄ Ａｂｄ−Ｅｌｒａｚｅｋ Ｈｅｌｍｙ× 石川 博之× 佐合 賢治× 原 竜介× 加藤 博敏× 安田 茂雄× 柳 剛× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: Progress of the novel carbon ion radiotherapy (CIRT) in the treatment of cancers has created the need for a method to accurately evaluate the response. We investigated whether L-[11C]methyl-methionine (11C–methionine) uptake at pre- and post-CIRT could be an early response predictor in patients with pelvic recurrence of rectal cancer. Patients and Methods: 11C–methionine positron emission tomography (PET) was performed prospectively in 53 patients with pelvic recurrence of rectal cancer before and 1 month after CIRT. 11C–methionine tumor uptake was measured by the tumor to muscle ratio (T/M ratio). The T/M ratios were evaluated in relation to clinical outcomes such as local re-recurrence, distant metastasis and survival. The response to CIRT was also judged by computed tomography (CT) and magnetic resonance imaging (MRI). 11C–methionine PET judgment was compared with CT/MRI judgment regarding the relevance to clinical outcome. Results: Baseline T/M ratio was 5.27±1.90 (mean±SD) in patients without developing local re-recurrence and 7.66±3.17 in patients with local re-recurrence (P=0.023, Mann-Whitney U test). Post-CIRT T/M ratios were 3.10±1.28 in patients without local re-recurrence and 6.15±2.98 in patients with local re-recurrence (p=0.006, Mann-Whitney U test). By Kaplan-Meier analysis with log-rank test, patients with a baseline T/M ratio of ≦7.6 or a post-CIRT T/M ratio of ≦5.0 had significant lower pelvic re-recurrence. However, the % change (reduction rate) from baseline to post-CIRT T/M ratio did not have significant relation to pelvic re-recurrence. There were no significant differences between 11C–methionine results (baseline T/M ratio, post-CIRT T/M ratio and % change) and other clinical parameters (distant metastasis and survival). Conclusion: 11C–methionine PET can be used for early prediction of local re-recurrence after CIRT. Because CIRT is local therapy, 11C–methionine PET cannot predict distant metastasis or survival after CIRT. |
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| 書誌情報 |
Molecular Imaging and Biology 巻 10, 号 6, p. 374-380, 発行日 2008-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1536-1632 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s11307-008-0156-1 | |||||
