{"created":"2023-05-15T14:35:18.882296+00:00","id":45492,"links":{},"metadata":{"_buckets":{"deposit":"0f704de6-b2a9-4e61-b389-6602c435cdf1"},"_deposit":{"created_by":1,"id":"45492","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45492"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045492","sets":["1"]},"author_link":["452014","452017","452021","452023","452003","452011","452019","452010","452006","452025","452016","452007","452004","451997","452009","451996","452018","451995","452012","452008","452015","452020","452022","452005","451999","452000","451998","452002","452013","452024","452001"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"380","bibliographicPageStart":"374","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Molecular Imaging and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Progress of the novel carbon ion radiotherapy (CIRT) in the treatment of cancers has created the need for a method to accurately evaluate the response. We investigated whether L-[11C]methyl-methionine (11C–methionine) uptake at pre- and post-CIRT could be an early response predictor in patients with pelvic recurrence of rectal cancer.\nPatients and Methods: 11C–methionine positron emission tomography (PET) was performed prospectively in 53 patients with pelvic recurrence of rectal cancer before and 1 month after CIRT. 11C–methionine tumor uptake was measured by the tumor to muscle ratio (T/M ratio). The T/M ratios were evaluated in relation to clinical outcomes such as local re-recurrence, distant metastasis and survival. The response to CIRT was also judged by computed tomography (CT) and magnetic resonance imaging (MRI). 11C–methionine PET judgment was compared with CT/MRI judgment regarding the relevance to clinical outcome. \nResults: Baseline T/M ratio was 5.27±1.90 (mean±SD) in patients without developing local re-recurrence and 7.66±3.17 in patients with local re-recurrence (P=0.023, Mann-Whitney U test). Post-CIRT T/M ratios were 3.10±1.28 in patients without local re-recurrence and 6.15±2.98 in patients with local re-recurrence (p=0.006, Mann-Whitney U test). By Kaplan-Meier analysis with log-rank test, patients with a baseline T/M ratio of ≦7.6 or a post-CIRT T/M ratio of ≦5.0 had significant lower pelvic re-recurrence. However, the % change (reduction rate) from baseline to post-CIRT T/M ratio did not have significant relation to pelvic re-recurrence. There were no significant differences between 11C–methionine results (baseline T/M ratio, post-CIRT T/M ratio and % change) and other clinical parameters (distant metastasis and survival).\nConclusion: 11C–methionine PET can be used for early prediction of local re-recurrence after CIRT. Because CIRT is local therapy, 11C–methionine PET cannot predict distant metastasis or survival after CIRT.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s11307-008-0156-1","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1536-1632","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koizumi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"451995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"451996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshikawa, Kyosan"}],"nameIdentifiers":[{"nameIdentifier":"451997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"451998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"451999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasebe, Mitsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"452000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohashi, Seiya"}],"nameIdentifiers":[{"nameIdentifier":"452001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mahmoud, Abd-Elrazek Helmy Sherif"}],"nameIdentifiers":[{"nameIdentifier":"452002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"452003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sagou, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"452004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hara, Ryusuke"}],"nameIdentifiers":[{"nameIdentifier":"452005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katou, Hirotoshi"}],"nameIdentifiers":[{"nameIdentifier":"452006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Shigeo"}],"nameIdentifiers":[{"nameIdentifier":"452007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanagi, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"452008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"452009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"452010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小泉 満","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉川 京燦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷部 充彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大橋 靖也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｓｈｅｒｉｆ Ｍａｈｍｏｕｄ Ａｂｄ−Ｅｌｒａｚｅｋ Ｈｅｌｍｙ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 博之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐合 賢治","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原 竜介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 博敏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 茂雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柳 剛","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"452025","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"11C-Methionine-PET for Evaluation of Carbon Ion Radiotherapy in Patients with Pelvic Recurrence of Rectal Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"11C-Methionine-PET for Evaluation of Carbon Ion Radiotherapy in Patients with Pelvic Recurrence of Rectal Cancer"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-21"},"publish_date":"2009-04-21","publish_status":"0","recid":"45492","relation_version_is_last":true,"title":["11C-Methionine-PET for Evaluation of Carbon Ion Radiotherapy in Patients with Pelvic Recurrence of Rectal Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:03:06.539497+00:00"}