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Monitoring of liver glycogen synthesis in diabetic patients using carbon-13 MR spectroscopy
https://repo.qst.go.jp/records/45454
https://repo.qst.go.jp/records/4545440f72765-321e-44ac-b32f-59f8d00edda4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-03-26 | |||||
| タイトル | ||||||
| タイトル | Monitoring of liver glycogen synthesis in diabetic patients using carbon-13 MR spectroscopy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tomiyasu, Moyoko
× Tomiyasu, Moyoko× Obata, Takayuki× Nishi, Yukio× Nakamoto, Hiromitsu× Nonaka, Hiroi× Takayama, Yukihisa× Joonas, Autio× Ikehira, Hiroo× Kanno, Iwao× 富安 もよこ× 小畠 隆行× 西 幸雄× 中本 泰充× 野中 博意× 高山 幸久× ヨーナス オーティオ× 池平 博夫× 菅野 巖 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate the relationship between liver glucose, glycogen, and plasma glucose in diabetic patients, in vivo liver carbon-13 magnetic resonance spectroscopy (13C MRS) with a clinical 3.0 T MR system was performed. Subjects were healthy male volunteers (n=5) and male type-2 diabetic patients (n=5). Pre- and during oral glucose tolerance tests (OGTT), 13C MR spectra without proton decoupling were acquired in a monitoring period of over six hours, and in total seven spectra were obtained from each subject. For OGTT, 75 g of glucose, including 5 g of [1-13C]glucose, was administered. The MR signals of liver [1-13C]glucose and glycogen were detected and their time-course changes were assessed in comparison with the plasma data obtained at screening. The correlations between the fasting plasma glucose level and liver glycogen/glucose rate (Spearman: p=-0.68, p<0.05, n=10) and the fasting plasma glucose level and liver glycogen peak/fasting rate (Spearman: p=-0.67, p<0.05, n=10) indicated that 13C MRS can perform noninvasive measurement of glycogen storage/degradation ability in the liver individually and can assist in tailor-made therapy for diabetes. In conclusion, 13C MRS has a potential to become a powerful tool in diagnosing diabetes multilaterally. |
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| 書誌情報 |
European Journal of Radiology 巻 73, 号 2, p. 300-304, 発行日 2008-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0720-048X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ejrad.2008.10.019 | |||||
