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Effect of trihexyphenidyl and L-Dopa on brain muscarinic cholinergic receptor binding measured by positron emission tomography.
https://repo.qst.go.jp/records/45431
https://repo.qst.go.jp/records/45431ecf5848a-bd73-402e-b197-89738d7d6047
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-02-25 | |||||
| タイトル | ||||||
| タイトル | Effect of trihexyphenidyl and L-Dopa on brain muscarinic cholinergic receptor binding measured by positron emission tomography. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shinoto, Hitoshi
× Shinoto, Hitoshi× Asahina, Masato× Inoue, Osamu× Suhara, Tetsuya× Tateno, Yukio× et.al× 篠遠 仁× 井上 修× 須原 哲也× 舘野 之男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of pharmacological intervention on brain muscarinic cholinergic receptor (mAChR) binding were assessed in seven patients with Parkinson's disease by positron emission tomography and carbon-11 labelled N-methyl-4-piperidyl benzilate ([11C]NMPB). [11C]NMPB was injected twice, approximately 2 hours apart, in each patient, to assess the effect of single doses of 4 mg of trihexyphenidyl (n=5) or 400 mg of L-dopa with 57 mg of benserazide (n=2) on the binding parameter of mAChRs (K3). There was a mean 28% inhibition of K3 values in the brain in the presence of trihexyphenidyl, which was assumed to reflect mAChR occupancy. No significant change in K3 was observed in the presence of L-dopa. This study demonstrates the feasibility of measuring mAChR occupancy by an anticholinergic medication with PET. | |||||
| 書誌情報 |
Journal of Neural Transmission. Parkinson's Disease and Dementia Section 巻 7, 号 1, p. 34-46, 発行日 1994-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0936-3076 | |||||
