{"created":"2023-05-15T14:35:14.859983+00:00","id":45431,"links":{},"metadata":{"_buckets":{"deposit":"efc85adc-e3f2-4f8a-a421-08d5c60a9128"},"_deposit":{"created_by":1,"id":"45431","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45431"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045431","sets":["1"]},"author_link":["451319","451322","451317","451323","451314","451321","451320","451315","451318","451316"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"46","bibliographicPageStart":"34","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Journal of Neural Transmission. Parkinson's Disease and Dementia Section"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effects of pharmacological intervention on brain muscarinic cholinergic receptor (mAChR) binding were assessed in seven patients with Parkinson's disease by positron emission tomography and carbon-11 labelled N-methyl-4-piperidyl benzilate ([11C]NMPB). [11C]NMPB was injected twice, approximately 2 hours apart, in each patient, to assess the effect of single doses of 4 mg of trihexyphenidyl (n=5) or 400 mg of L-dopa with 57 mg of benserazide (n=2) on the binding parameter of mAChRs (K3). There was a mean 28% inhibition of K3 values in the brain in the presence of trihexyphenidyl, which was assumed to reflect mAChR occupancy. No significant change in K3 was observed in the presence of L-dopa. This study demonstrates the feasibility of measuring mAChR occupancy by an anticholinergic medication with PET.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0936-3076","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shinoto, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"451314","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Asahina, Masato"}],"nameIdentifiers":[{"nameIdentifier":"451315","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Osamu"}],"nameIdentifiers":[{"nameIdentifier":"451316","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"451317","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tateno, Yukio"}],"nameIdentifiers":[{"nameIdentifier":"451318","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"451319","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"451320","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上 修","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"451321","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"451322","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"舘野 之男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"451323","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of trihexyphenidyl and L-Dopa on brain muscarinic cholinergic receptor binding measured by positron emission tomography.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of trihexyphenidyl and L-Dopa on brain muscarinic cholinergic receptor binding measured by positron emission tomography."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-02-25"},"publish_date":"2009-02-25","publish_status":"0","recid":"45431","relation_version_is_last":true,"title":["Effect of trihexyphenidyl and L-Dopa on brain muscarinic cholinergic receptor binding measured by positron emission tomography."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:03:48.647556+00:00"}