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Aberrant activation of interleukin-9 receptor and downstream Stat3/5 in primary T-cell lymphomas in vivo susceptible B6 and resistant C3H mice
https://repo.qst.go.jp/records/45357
https://repo.qst.go.jp/records/453575fb4d221-a27f-45d5-9829-c68ef0375e10
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-12-22 | |||||
| タイトル | ||||||
| タイトル | Aberrant activation of interleukin-9 receptor and downstream Stat3/5 in primary T-cell lymphomas in vivo susceptible B6 and resistant C3H mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shang, Yi
× Shang, Yi× Kakinuma, Shizuko× Amasaki, Yoshiko× Nishimura, Mayumi× Kobayashi, Yoshiro× Shimada, Yoshiya× 尚 奕× 柿沼 志津子× 甘崎 佳子× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | IL-2 family cytokine-mediated signal transduction plays important roles in not only normal development but also malignant transformation of lymphoid cell. Unusual mRNA expression of receptors has been demonstrated in primary T-ALL and HTLV-I-transformed lymphoid cells. Little is known, however, about the status of receptor activation and downstream signal transduction in primary lymphomas in vivo. We here demonstrated that IL-9Ra was exceptionally highly expressed and phophorylated in primary T-cell lymphoma (TL). IL-9Ra proteins in TL were heterogeneous due to different glycosylation. Downstream Stat3 and 5, but not Stat1, were also phosphorylated. There was a clear strain difference between susceptible C57BL/6 and resistant C3H mice in Stat3 and 5 activation and expression of Cyclin D1. These findings suggest that aberrant expression, modification, and activation of IL9Ra and Stat proteins contribute to in vivo growth of TL in a manner linking to the genetic susceptibility to TL induction. | |||||
| 書誌情報 |
In Vivo 巻 22, 号 6, p. 713-720, 発行日 2008 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0258-851X | |||||
