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  1. 原著論文

Aberrant activation of interleukin-9 receptor and downstream Stat3/5 in primary T-cell lymphomas in vivo susceptible B6 and resistant C3H mice

https://repo.qst.go.jp/records/45357
https://repo.qst.go.jp/records/45357
5fb4d221-a27f-45d5-9829-c68ef0375e10
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-12-22
タイトル
タイトル Aberrant activation of interleukin-9 receptor and downstream Stat3/5 in primary T-cell lymphomas in vivo susceptible B6 and resistant C3H mice
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Shang, Yi

× Shang, Yi

WEKO 450565

Shang, Yi

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Kakinuma, Shizuko

× Kakinuma, Shizuko

WEKO 450566

Kakinuma, Shizuko

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Amasaki, Yoshiko

× Amasaki, Yoshiko

WEKO 450567

Amasaki, Yoshiko

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Nishimura, Mayumi

× Nishimura, Mayumi

WEKO 450568

Nishimura, Mayumi

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Kobayashi, Yoshiro

× Kobayashi, Yoshiro

WEKO 450569

Kobayashi, Yoshiro

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Shimada, Yoshiya

× Shimada, Yoshiya

WEKO 450570

Shimada, Yoshiya

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尚 奕

× 尚 奕

WEKO 450571

en 尚 奕

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柿沼 志津子

× 柿沼 志津子

WEKO 450572

en 柿沼 志津子

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甘崎 佳子

× 甘崎 佳子

WEKO 450573

en 甘崎 佳子

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西村 まゆみ

× 西村 まゆみ

WEKO 450574

en 西村 まゆみ

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島田 義也

× 島田 義也

WEKO 450575

en 島田 義也

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抄録
内容記述タイプ Abstract
内容記述 IL-2 family cytokine-mediated signal transduction plays important roles in not only normal development but also malignant transformation of lymphoid cell. Unusual mRNA expression of receptors has been demonstrated in primary T-ALL and HTLV-I-transformed lymphoid cells. Little is known, however, about the status of receptor activation and downstream signal transduction in primary lymphomas in vivo. We here demonstrated that IL-9Ra was exceptionally highly expressed and phophorylated in primary T-cell lymphoma (TL). IL-9Ra proteins in TL were heterogeneous due to different glycosylation. Downstream Stat3 and 5, but not Stat1, were also phosphorylated. There was a clear strain difference between susceptible C57BL/6 and resistant C3H mice in Stat3 and 5 activation and expression of Cyclin D1. These findings suggest that aberrant expression, modification, and activation of IL9Ra and Stat proteins contribute to in vivo growth of TL in a manner linking to the genetic susceptibility to TL induction.
書誌情報 In Vivo

巻 22, 号 6, p. 713-720, 発行日 2008
ISSN
収録物識別子タイプ ISSN
収録物識別子 0258-851X
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