{"created":"2023-05-15T14:35:09.957897+00:00","id":45357,"links":{},"metadata":{"_buckets":{"deposit":"80281398-98d2-498e-86aa-6d6e4611fb10"},"_deposit":{"created_by":1,"id":"45357","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45357"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045357","sets":["1"]},"author_link":["450571","450575","450573","450567","450565","450568","450570","450569","450572","450574","450566"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"720","bibliographicPageStart":"713","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"In Vivo"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"IL-2 family cytokine-mediated signal transduction plays important roles in not only normal development but also malignant transformation of lymphoid cell.  Unusual mRNA expression of receptors has been demonstrated in primary T-ALL and HTLV-I-transformed lymphoid cells.   Little is known, however, about the status of receptor activation and downstream signal transduction in primary lymphomas in vivo. We here demonstrated that IL-9Ra was exceptionally highly expressed and phophorylated in primary T-cell lymphoma (TL).  IL-9Ra proteins in TL were heterogeneous due to different glycosylation.  Downstream Stat3 and 5, but not Stat1, were also phosphorylated.  There was a clear strain difference between susceptible C57BL/6 and resistant C3H mice in Stat3 and 5 activation and expression of Cyclin D1.  These findings suggest that aberrant expression, modification, and activation of IL9Ra and Stat proteins contribute to in vivo growth of TL in a manner linking to the genetic susceptibility to TL induction.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0258-851X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shang, Yi"}],"nameIdentifiers":[{"nameIdentifier":"450565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"450566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Amasaki, Yoshiko"}],"nameIdentifiers":[{"nameIdentifier":"450567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"450568","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Yoshiro"}],"nameIdentifiers":[{"nameIdentifier":"450569","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"450570","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚 奕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"450571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"450572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甘崎 佳子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"450573","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"450574","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"450575","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Aberrant activation of interleukin-9 receptor and downstream Stat3/5 in primary T-cell lymphomas in vivo susceptible B6 and resistant C3H mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aberrant activation of interleukin-9 receptor and downstream Stat3/5 in primary T-cell lymphomas in vivo susceptible B6 and resistant C3H mice"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-12-22"},"publish_date":"2008-12-22","publish_status":"0","recid":"45357","relation_version_is_last":true,"title":["Aberrant activation of interleukin-9 receptor and downstream Stat3/5 in primary T-cell lymphomas in vivo susceptible B6 and resistant C3H mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:04:40.614645+00:00"}