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Quantitative Analysis of NK1 Receptor in the Human Brain Using PET with 18F-FE-SPA-RQ
https://repo.qst.go.jp/records/45323
https://repo.qst.go.jp/records/45323a345ec9b-ae21-45e2-8ae6-095511b72281
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-11-25 | |||||
| タイトル | ||||||
| タイトル | Quantitative Analysis of NK1 Receptor in the Human Brain Using PET with 18F-FE-SPA-RQ | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okumura, Masaki
× Okumura, Masaki× Arakawa, Ryosuke× Ito, Hiroshi× Seki, Chie× Takahashi, Hidehiko× Takano, Harumasa× Haneda, Eisuke× Nakao, Ryuji× Suzuki, Hidenori× Suzuki, Kazutoshi× Okubo, Yoshiro× Suhara, Tetsuya× 奥村 正紀× 荒川 亮介× 伊藤 浩× 関 千江× 高橋 英彦× 高野 晴成× 羽田 栄輔× 鈴木 秀典× 鈴木 和年× 大久保 善朗× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | (18)F-fluoroethyl-SPA-RQ ((18)F-FE-SPA-RQ) was recently developed as a radioligand for the measurement of neurokinin 1 (NK(1)) receptor with PET. In this study, we used (18)F-FE-SPA-RQ with PET to visualize and quantify NK(1) receptor in the human brain. METHODS: PET scans were performed on 7 healthy men after intravenous injection of (18)F-FE-SPA-RQ. Binding potential (BP(ND)) was calculated by the indirect kinetic, simplified reference tissue model (SRTM), and ratio methods. The indirect kinetic method was used as the gold standard method and was compared with the SRTM method, with scan times of 180, 270, and 330 min, and with the ratio method, with time integration intervals of 120-180, 210-270, and 300-330 min. The cerebellum was used as the reference brain region. RESULTS: Regional radioactivity was highest in the caudate head and putamen; mid level in the parahippocampus, cerebral cortex, and thalamus; and lowest in the cerebellum. BP(ND) values by the indirect kinetic method were 3.15 +/- 0.36, 3.11 +/- 0.66, 1.17 +/- 0.25, and 0.46 +/- 0.14 in the caudate, putamen, parahippocampal region, and thalamus, respectively. For cerebral cortical regions, BP(ND) values by the indirect kinetic method were 0.94 +/- 0.23, 0.82 +/- 0.15, 0.76 +/- 0.15, and 0.69 +/- 0.16 in the occipital, temporal, frontal, and anterior cingulate cortices, respectively. BP(ND) values by the SRTM and ratio methods were in good agreement with those by the indirect kinetic method (r = 0.94-0.98). CONCLUSION: The regional distribution of (18)F-FE-SPA-RQ was in agreement with previous PET studies and postmortem studies of NK(1) receptor in the human brain. The ratio method will be useful for clinical research of psychiatric disorders, for the estimation of NK(1) receptor without arterial blood sampling and long dynamic PET. | |||||
| 書誌情報 |
Journal of Nuclear Medicine 巻 49, 号 11, p. 1749-1755, 発行日 2008-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0161-5505 | |||||
