@article{oai:repo.qst.go.jp:00045323,
 author = {Okumura, Masaki and Arakawa, Ryosuke and Ito, Hiroshi and Seki, Chie and Takahashi, Hidehiko and Takano, Harumasa and Haneda, Eisuke and Nakao, Ryuji and Suzuki, Hidenori and Suzuki, Kazutoshi and Okubo, Yoshiro and Suhara, Tetsuya and 奥村 正紀 and 荒川 亮介 and 伊藤 浩 and 関 千江 and 高橋 英彦 and 高野 晴成 and 羽田 栄輔 and 鈴木 秀典 and 鈴木 和年 and 大久保 善朗 and 須原 哲也},
 issue = {11},
 journal = {Journal of Nuclear Medicine},
 month = {Nov},
 note = {(18)F-fluoroethyl-SPA-RQ ((18)F-FE-SPA-RQ) was recently developed as a radioligand for the measurement of neurokinin 1 (NK(1)) receptor with PET. In this study, we used (18)F-FE-SPA-RQ with PET to visualize and quantify NK(1) receptor in the human brain. METHODS: PET scans were performed on 7 healthy men after intravenous injection of (18)F-FE-SPA-RQ. Binding potential (BP(ND)) was calculated by the indirect kinetic, simplified reference tissue model (SRTM), and ratio methods. The indirect kinetic method was used as the gold standard method and was compared with the SRTM method, with scan times of 180, 270, and 330 min, and with the ratio method, with time integration intervals of 120-180, 210-270, and 300-330 min. The cerebellum was used as the reference brain region. RESULTS: Regional radioactivity was highest in the caudate head and putamen; mid level in the parahippocampus, cerebral cortex, and thalamus; and lowest in the cerebellum. BP(ND) values by the indirect kinetic method were 3.15 +/- 0.36, 3.11 +/- 0.66, 1.17 +/- 0.25, and 0.46 +/- 0.14 in the caudate, putamen, parahippocampal region, and thalamus, respectively. For cerebral cortical regions, BP(ND) values by the indirect kinetic method were 0.94 +/- 0.23, 0.82 +/- 0.15, 0.76 +/- 0.15, and 0.69 +/- 0.16 in the occipital, temporal, frontal, and anterior cingulate cortices, respectively. BP(ND) values by the SRTM and ratio methods were in good agreement with those by the indirect kinetic method (r = 0.94-0.98). CONCLUSION: The regional distribution of (18)F-FE-SPA-RQ was in agreement with previous PET studies and postmortem studies of NK(1) receptor in the human brain. The ratio method will be useful for clinical research of psychiatric disorders, for the estimation of NK(1) receptor without arterial blood sampling and long dynamic PET.},
 pages = {1749--1755},
 title = {Quantitative Analysis of NK1 Receptor in the Human Brain Using PET with 18F-FE-SPA-RQ},
 volume = {49},
 year = {2008}
}