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Multimodal Silica-Shelled Quantum Dots: Direct Intracellular Delivery, Photosensitization, Toxic, and Microcirculation Effects
https://repo.qst.go.jp/records/45318
https://repo.qst.go.jp/records/453186a4cc8e7-c0e8-4e43-9222-931427ee0c09
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-11-18 | |||||
| タイトル | ||||||
| タイトル | Multimodal Silica-Shelled Quantum Dots: Direct Intracellular Delivery, Photosensitization, Toxic, and Microcirculation Effects | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bakalova-Zheleva, Rumiana
× Bakalova-Zheleva, Rumiana× Zhelev, Zhivko× Aoki, Ichio× Masamoto, Kazuto× Mileva, Milka× Obata, Takayuki× Higuchi, Makoto× Veselina, Gadjeva× Kanno, Iwao× バカロバ ルミアナ× Ｚｈｅｌｅｖ Ｚｈｉｖｋｏ× 青木 伊知男× 正本 和人× 小畠 隆行× 樋口 真人× 菅野 巖 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the present study, we describe a multimodal QD probe with combined fluorescent and paramagnetic properties, based on silica-shelled single QD micelles with incorporated paramagnetic substances [tris(2,2,6,6-tetramethyl-3,5-heptanedionate)/gadolinium] into the micelle and/or silica coat. The probe was characterized with high photoluminescence quantum yield and good positive MRI contrast, low cytotoxicity, and easy intracellular delivery in viable cells. The intravenous administration of the probe in experimental animals did not affect significantly the physiological parameters and microcirculation (e.g., heart rate, blood pressure, diameter and shape of blood vessels), which makes it appropriate for tracing of blood circulation and in vivo multimodal imaging using fluorescent confocal microscopy, two-photon microscopy, and MRI. | |||||
| 書誌情報 |
Bioconjugate Chemistry 巻 19, 号 6, p. 1135-1142, 発行日 2008-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1043-1802 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1021/bc700431c | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://pubs.acs.org | |||||
| 関連名称 | http://pubs.acs.org | |||||
