@article{oai:repo.qst.go.jp:00045318,
 author = {Bakalova-Zheleva, Rumiana and Zhelev, Zhivko and Aoki, Ichio and Masamoto, Kazuto and Mileva, Milka and Obata, Takayuki and Higuchi, Makoto and Veselina, Gadjeva and Kanno, Iwao and バカロバ ルミアナ and Ｚｈｅｌｅｖ Ｚｈｉｖｋｏ and 青木 伊知男 and 正本 和人 and 小畠 隆行 and 樋口 真人 and 菅野 巖},
 issue = {6},
 journal = {Bioconjugate Chemistry},
 month = {May},
 note = {In the present study, we describe a multimodal QD probe with combined fluorescent and paramagnetic properties, based on silica-shelled single QD micelles with incorporated paramagnetic substances [tris(2,2,6,6-tetramethyl-3,5-heptanedionate)/gadolinium] into the micelle and/or silica coat. The probe was characterized with high photoluminescence quantum yield and good positive MRI contrast, low cytotoxicity, and easy intracellular delivery in viable cells. The intravenous administration of the probe in experimental animals did not affect significantly the physiological parameters and microcirculation (e.g., heart rate, blood pressure, diameter and shape of blood vessels), which makes it appropriate for tracing of blood circulation and in vivo multimodal imaging using fluorescent confocal microscopy, two-photon microscopy, and MRI.},
 pages = {1135--1142},
 title = {Multimodal Silica-Shelled Quantum Dots: Direct Intracellular Delivery, Photosensitization, Toxic, and Microcirculation Effects},
 volume = {19},
 year = {2008}
}