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Distinct structural abnormalities of chromosomes 11 and 12 associated with loss of heterozygosity in X-ray-induced mouse thymic lymphomas.
https://repo.qst.go.jp/records/45296
https://repo.qst.go.jp/records/45296ddc3694a-f703-4a31-92b2-75c1ff422ec5
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-10 | |||||
| タイトル | ||||||
| タイトル | Distinct structural abnormalities of chromosomes 11 and 12 associated with loss of heterozygosity in X-ray-induced mouse thymic lymphomas. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshida, Mitsuaki
× Yoshida, Mitsuaki× Nakata, Akifumi× Akiyma, Miho× Kakinuma, Shizuko× Sado, Toshihiko× Nishimura, Mayumi× Shimada, Yoshiya× 吉田 光明× 中田 章史× 穐山 美穂× 柿沼 志津子× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Loss of heterozygosity (LOH) plays an important role in leukemogenesis via inactivation of tumor suppressor genes. Recent studies have demonstrated that mouse thymic lymphomas (TLs), a suitable model for the mechanistic study on human acute lymphoblastic leukemia, show frequent LOH on chromosomes 4 (p15/p16), 11 (Ikaros), 12 (Bcl11b), 19 (Pten) and X. Little data, however, are available for the mechanism of LOH, yet. In this study, we re-evaluated chromosome abnormality and loss of heterozygosity in 26 TL induced by X-rays in C57BL/6 (B6), C3H and F1 (B6 x C3H) mice, using quinacrine-Hoechst double staining method and chromosome painting technique. Chromosomally abnormal cells were present in 25 TLs examined (25/26, 96%). Most frequent abnormality was trisomy or partial trisomy of chromosome 15 (16/26, 62%), being consistent with previous studies. Structural abnormalities of chromosome 11 with interstitial deletion of proximal region and chromosome 12 with translocation with deletion of distal region were newly identified in 7 (27%) and 12 (46%) cases, respectively. These results indicate that the distinct mechanism contributes to LOH of each tumor suppressor gene on different chromosomal location. | |||||
| 書誌情報 |
Cancer Genetics and Cytogenetics 巻 179, 号 1, p. 1-10, 発行日 2007-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0165-4608 | |||||
