{"created":"2023-05-15T14:35:05.944917+00:00","id":45296,"links":{},"metadata":{"_buckets":{"deposit":"4406edff-9783-4ddc-9c3e-79ba88521949"},"_deposit":{"created_by":1,"id":"45296","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45296"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045296","sets":["1"]},"author_link":["449988","449986","449987","449996","449989","449984","449990","449993","449994","449992","449995","449991","449985"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographicVolumeNumber":"179","bibliographic_titles":[{"bibliographic_title":"Cancer Genetics and Cytogenetics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Loss of heterozygosity (LOH) plays an important role in leukemogenesis via inactivation of tumor suppressor genes.  Recent studies have demonstrated that mouse thymic lymphomas (TLs), a suitable model for the mechanistic study on human acute lymphoblastic leukemia, show frequent LOH on chromosomes 4 (p15/p16), 11 (Ikaros), 12 (Bcl11b), 19 (Pten) and X.  Little data, however, are available for the mechanism of LOH, yet.  In this study, we re-evaluated chromosome abnormality and loss of heterozygosity in 26 TL induced by X-rays in C57BL/6 (B6), C3H and F1 (B6 x C3H) mice, using quinacrine-Hoechst double staining method and chromosome painting technique. Chromosomally abnormal cells were present in 25 TLs examined (25/26, 96%).  Most frequent abnormality was trisomy or partial trisomy of chromosome 15 (16/26, 62%), being consistent with previous studies. Structural abnormalities of chromosome 11 with interstitial deletion of proximal region and chromosome 12 with translocation with deletion of distal region were newly identified in 7 (27%) and 12 (46%) cases, respectively.  These results indicate that the distinct mechanism contributes to LOH of each tumor suppressor gene on different chromosomal location.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0165-4608","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Mitsuaki"}],"nameIdentifiers":[{"nameIdentifier":"449984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakata, Akifumi"}],"nameIdentifiers":[{"nameIdentifier":"449985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akiyma, Miho"}],"nameIdentifiers":[{"nameIdentifier":"449986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"449987","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sado, Toshihiko"}],"nameIdentifiers":[{"nameIdentifier":"449988","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"449989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"449990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 光明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449991","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中田 章史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"穐山 美穂","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449996","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Distinct structural abnormalities of chromosomes 11 and 12 associated with loss of heterozygosity in X-ray-induced mouse thymic lymphomas.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Distinct structural abnormalities of chromosomes 11 and 12 associated with loss of heterozygosity in X-ray-induced mouse thymic lymphomas."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-10"},"publish_date":"2008-10-10","publish_status":"0","recid":"45296","relation_version_is_last":true,"title":["Distinct structural abnormalities of chromosomes 11 and 12 associated with loss of heterozygosity in X-ray-induced mouse thymic lymphomas."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:05:24.602839+00:00"}