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Upregulation of Stress-response Genes with Cell Cycle Arrest Induced by Carbon Ion Irradiation in Multiple Murine Tumors Models.
https://repo.qst.go.jp/records/45278
https://repo.qst.go.jp/records/4527898e8681a-333a-4302-b847-00932a5844e1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-30 | |||||
| タイトル | ||||||
| タイトル | Upregulation of Stress-response Genes with Cell Cycle Arrest Induced by Carbon Ion Irradiation in Multiple Murine Tumors Models. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imadome, Kaori
× Imadome, Kaori× Iwakawa, Mayumi× Nojiri, Kazunori× Tamaki, Tomoaki× Sakai, Minako× Nakawatari, Miyako× Moritake, Takashi× Yanagisawa, Mitsuru× Nakamura, Etsuko× Tsujii, Hirohiko× Imai, Takashi× 今留 香織× 岩川 眞由美× 野尻 和典× 田巻 倫明× 酒井 美奈子× 中渡 美也子× 盛武 敬× 柳澤 充× 辻井 博彦× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: To elucidate the in vivo biological effects induced by carbon-ion irradiation using comprehensive expression analysis. \nMaterials and Methods: We examined gene expression changes after carbon-ion (C-ion) irradiation (290 MeV/m, SOBP 6 cm middle, 50 kev/MUm) with a single dose of 30 Gy in four mouse tumors (NR-S1, SCCVII, NFSa, and #8520) transplanted into the hind legs of C3H/HeNrs mice, using 44K single-color oligo-microarrays at 6 hours (h), 1 day, and 3 days after irradiation. Gamma rays of 30 Gy and 50 Gy were used as a reference beam. Identification of C-ion-responsive genes was based on a false discovery rate of < 5% using the Wilcoxon test (P < 0.001) and the Benjamini-Hochberg correction. \nResults: In all tumors, the level of expression of several tens of genes, including Ccl3, Ccng1, Cd80, Cdkn1a, Cxcl2, IL7r, Lrdd, Mgmt, Mmp8, and Polk, was significantly altered 6 h and day 1 following C-ion irradiation. At day 3, several hundred genes, many of which are also classified as stress-response or cell-communication genes, including Tnfrsf5, Ikbke, and Icam1, were upregulated following C-ion irradiation. The expression level of the majority of these genes was similar following GAMMA-ray treatment, although the change was not as extensive and intertumor variance was apparent. Several genes, including Ikbke, Serpina3n, and Saa3, responded differentially following C-ion irradiation than after GAMMA-ray irradiation. Pathological investigation and immunohistochemical analysis of Cdkn1a revealed cell cycle arrest with mitotic catastrophe in tumors irradiated by C-ions. \nConclusions: This study revealed significant C-ion induced upregulation of stress-responsive and cell-communication genes common to different tumor types. These findings provide evidence for the efficacy of this modality for the treatment of local tumors. |
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| 書誌情報 |
Cancer Biology & Therapy 巻 7, 号 2, p. 208-217, 発行日 2008-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1538-4047 | |||||
