{"created":"2023-05-15T14:35:04.486812+00:00","id":45278,"links":{},"metadata":{"_buckets":{"deposit":"85370d35-c5cf-4e11-bf72-1b011466bad2"},"_deposit":{"created_by":1,"id":"45278","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45278"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045278","sets":["1"]},"author_link":["449781","449791","449789","449793","449790","449782","449783","449797","449798","449785","449792","449784","449794","449795","449788","449796","449799","449800","449801","449786","449787"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"217","bibliographicPageStart":"208","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Cancer Biology & Therapy"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: To elucidate the in vivo biological effects induced by carbon-ion irradiation using comprehensive expression analysis. \n\\nMaterials and Methods: We examined gene expression changes after carbon-ion (C-ion) irradiation (290 MeV/m, SOBP 6 cm middle, 50 kev/MUm) with a single dose of 30 Gy in four mouse tumors (NR-S1, SCCVII, NFSa, and #8520) transplanted into the hind legs of C3H/HeNrs mice, using 44K single-color oligo-microarrays at 6 hours (h), 1 day, and 3 days after irradiation. Gamma rays of 30 Gy and 50 Gy were used as a reference beam. Identification of C-ion-responsive genes was based on a false discovery rate of < 5% using the Wilcoxon test (P < 0.001) and the Benjamini-Hochberg correction. \n\\nResults: In all tumors, the level of expression of several tens of genes, including Ccl3, Ccng1, Cd80, Cdkn1a, Cxcl2, IL7r, Lrdd, Mgmt, Mmp8, and Polk, was significantly altered 6 h and day 1 following C-ion irradiation. At day 3, several hundred genes, many of which are also classified as stress-response or cell-communication genes, including Tnfrsf5, Ikbke, and Icam1, were upregulated following C-ion irradiation. The expression level of the majority of these genes was similar following GAMMA-ray treatment, although the change was not as extensive and intertumor variance was apparent. Several genes, including Ikbke, Serpina3n, and Saa3, responded differentially following C-ion irradiation than after GAMMA-ray irradiation. Pathological investigation and immunohistochemical analysis of Cdkn1a revealed cell cycle arrest with mitotic catastrophe in tumors irradiated by C-ions. \n\\nConclusions: This study revealed significant C-ion induced upregulation of stress-responsive and cell-communication genes common to different tumor types. These findings provide evidence for the efficacy of this modality for the treatment of local tumors.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1538-4047","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imadome, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"449781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"449782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nojiri, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"449783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamaki, Tomoaki"}],"nameIdentifiers":[{"nameIdentifier":"449784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Minako"}],"nameIdentifiers":[{"nameIdentifier":"449785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakawatari, Miyako"}],"nameIdentifiers":[{"nameIdentifier":"449786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moritake, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"449787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanagisawa, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"449788","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Etsuko"}],"nameIdentifiers":[{"nameIdentifier":"449789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"449790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"449791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今留 香織","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野尻 和典","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田巻 倫明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"酒井 美奈子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中渡 美也子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"盛武 敬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柳澤 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449801","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Upregulation of Stress-response Genes with Cell Cycle Arrest Induced by Carbon Ion Irradiation in Multiple Murine Tumors Models.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Upregulation of Stress-response Genes with Cell Cycle Arrest Induced by Carbon Ion Irradiation in Multiple Murine Tumors Models."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-09-30"},"publish_date":"2008-09-30","publish_status":"0","recid":"45278","relation_version_is_last":true,"title":["Upregulation of Stress-response Genes with Cell Cycle Arrest Induced by Carbon Ion Irradiation in Multiple Murine Tumors Models."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:05:37.981698+00:00"}