WEKO3
アイテム
Biophysical calculation of cell survival probabilities using amorphous track structure models for heavy-ion irradiation
https://repo.qst.go.jp/records/45204
https://repo.qst.go.jp/records/4520469749bf0-2e4d-4c39-ab30-8aba2abe4bea
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-06-19 | |||||
| タイトル | ||||||
| タイトル | Biophysical calculation of cell survival probabilities using amorphous track structure models for heavy-ion irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kase, Yuuki
× Kase, Yuuki× Kanai, Tatsuaki× Matsufuji, Naruhiro× Furusawa, Yoshiya× et.al× 加瀬 優紀× 金井 達明× 松藤 成弘× 古澤 佳也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Both the microdosimetric kinetic model (MKM) and the local effect model (LEM) can be used to calculate the surviving fraction of cells irradiated by high-energy ion beams. In this study, amorphous track structuremodels instead of the stochastic energy deposition are used for the MKM calculation, and it is found that the MKM calculation is useful for predicting the survival curves of the mammalian cells in vitro for 3He-, 12C- and 20Ne-ion beams. The survival curves are also calculated by two different implementations of the LEM, which inherently used an amorphous track structure model. The results calculated in this manner show good agreement with the experimental results especially for the modified LEM. These results are compared to those calculated by the MKM. Comparison of the two models reveals that both models require three basic constituents: target geometry, photon survival curve and track structure, although the implementation of each model is significantly different. In the context of the amorphous track structure model, the difference between the MKM and LEM is primarily the result of different approaches calculating the biological effects of the extremely high local dose in the center of the ion track. |
|||||
| 書誌情報 |
Physics in Medicine and Biology 巻 53, 号 1, p. 37-59, 発行日 2007-12 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/0031-9155/53/1/003 | |||||
