WEKO3
-
RootNode
アイテム
Gene expression analysis in human malignant melanoma cell lines exposed to carbon beams
https://repo.qst.go.jp/records/45168
https://repo.qst.go.jp/records/45168691f7428-a048-410f-be35-fc4b48db076f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-05-27 | |||||
| タイトル | ||||||
| タイトル | Gene expression analysis in human malignant melanoma cell lines exposed to carbon beams | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Yoshitaka
× Matsumoto, Yoshitaka× Iwakawa, Mayumi× Furusawa, Yoshiya× Ishikawa, Kenichi× Aoki, Mizuho× Imadome, Kaori× Matsumoto, Izumi× Tsujii, Hirohiko× Ando, Koichi× Imai, Takashi× 松本 孔貴× 岩川 眞由美× 古澤 佳也× 石川 顕一× 青木 瑞穂× 今留 香織× 松本 いづみ× 辻井 博彦× 安藤 興一× 今井 高志 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To elucidate the molecular changes in response to carbon beams (C-ions) in melanoma. Materials and methods: We examined expression profiles of 6 melanoma cell lines exposed to C-ions or X-rays with 2 Gy using single-color microarrays. Results: Twenty-two genes, including nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA), responded to C-ions in all six cell lines, based on analysis of variance (ANOVA) filtering (p < 0.001). We found 173 genes that responded in common to C-ions in four cell lines. We identified many down-regulated genes including the cell cycle - related genes that were more responsive to C-ions than X-rays. In contrast, most of the up-regulated genes including the tumor protein p53 (p53) target genes responded to both C-ions and X-rays. C-ions induced G2/M arrest significantly more than X-rays at 30 h (p < 0.05). Conclusion: Our findings suggest that down-regulation of gene expression plays a key role in the response to C-ions. Regulation of cell cycle - related genes and induction of prolonged G2/M arrest may be responsible for the extra sensitivity to C-ions, whereas p53-related genes may have similar roles in the sensitivities to both C-ions and X-rays. | |||||
| 書誌情報 |
International Journal of Radiation Biology 巻 84, 号 4, p. 299-314, 発行日 2008-03 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/09553000801953334 | |||||
Share
Cite as
Matsumoto, Yoshitaka, Iwakawa, Mayumi, Furusawa, Yoshiya, Ishikawa, Kenichi, Aoki, Mizuho, Imadome, Kaori, Matsumoto, Izumi, Tsujii, Hirohiko, Ando, Koichi, Imai, Takashi, 松本 孔貴, 岩川 眞由美, 古澤 佳也, 石川 顕一, 青木 瑞穂, 今留 香織, 松本 いづみ, 辻井 博彦, 安藤 興一, 今井 高志, 2008, Gene expression analysis in human malignant melanoma cell lines exposed to carbon beams: 299–314 p.
Loading...
