@article{oai:repo.qst.go.jp:00045168,
 author = {Matsumoto, Yoshitaka and Iwakawa, Mayumi and Furusawa, Yoshiya and Ishikawa, Kenichi and Aoki, Mizuho and Imadome, Kaori and Matsumoto, Izumi and Tsujii, Hirohiko and Ando, Koichi and Imai, Takashi and 松本 孔貴 and 岩川 眞由美 and 古澤 佳也 and 石川 顕一 and 青木 瑞穂 and 今留 香織 and 松本 いづみ and 辻井 博彦 and 安藤 興一 and 今井 高志},
 issue = {4},
 journal = {International Journal of Radiation Biology},
 month = {Mar},
 note = {Purpose: To elucidate the molecular changes in response to carbon beams (C-ions) in melanoma. Materials and methods: We examined expression profiles of 6 melanoma cell lines exposed to C-ions or X-rays with 2 Gy using single-color microarrays. Results: Twenty-two genes, including nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA), responded to C-ions in all six cell lines, based on analysis of variance (ANOVA) filtering (p < 0.001). We found 173 genes that responded in common to C-ions in four cell lines. We identified many down-regulated genes including the cell cycle - related genes that were more responsive to C-ions than X-rays. In contrast, most of the up-regulated genes including the tumor protein p53 (p53) target genes responded to both C-ions and X-rays. C-ions induced G2/M arrest significantly more than X-rays at 30 h (p < 0.05). Conclusion: Our findings suggest that down-regulation of gene expression plays a key role in the response to C-ions. Regulation of cell cycle - related genes and induction of prolonged G2/M arrest may be responsible for the extra sensitivity to C-ions, whereas p53-related genes may have similar roles in the sensitivities to both C-ions and X-rays.},
 pages = {299--314},
 title = {Gene expression analysis in human malignant melanoma cell lines exposed to carbon beams},
 volume = {84},
 year = {2008}
}