Carbon Ion Radiotherapy for Stage I Non-small Cell Lung Cancer Using a Regimen of Four Fractions during 1 Week

Background:A phase I/II study was first conducted for the treatment of stage I non-small cell lung cancer(NSCLC)from 1994 to 1999 to determine the optimal dose.On the basis on the results,a phase II study using a regimen of four fractions during 1 week was performed.The purpose of the present study was to determine the local control and 5-year survival rates.
Methods:From December 2000 to November 2003,79 patients with 80 primary lesions were treated. Using a fixed dose of 52.8 GyE for stage IA NSCLC and 60.0 GyE for stage IB NSCLC in four fractions during 1 week,the primary tumors were irradiated with carbon beams alone.The average age of the patients was 74.8 years.Sixty-two(78.5%)of these patients were medically inoperable.Local control and survival were determined using the Kaplan-Meier method.The data were statistically processed using the log-rank test.
Results:All patients were observed for a minimum of 3 years or until death,with a median follow-up time of 38.6 months,ranging from 2.5 to 72.2 months.The local control rate for all patients was 90%(T1:98%,T2:80%).The patients'5-year lung cancer-specific survival rate was 68%(IA:87%,IB:42%).The overall survival was 45%(IA:62%,IB:25%).Harf of the deaths were attributable to intercurrent diseases.No toxic reactions in the lung greater than grade 3 were detected.
Conclusion:Carbon ion beam radiotherapy with a regimen of four fractions during 1 week has been proven as a valid alternative to surgery for stage INCLC and to offer particular benefits,especially for elderly and inoperable patients.

書誌情報

Journal of Thoracic Oncology

巻 2, 号 10, p. 916-926, 発行日 2007-10

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収録物識別子タイプ

ISSN

収録物識別子

1556-0864

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2023-05-16 00:07:05.605033

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