@article{oai:repo.qst.go.jp:00045150,
 author = {Miyamoto, Tadaaki and Baba, Masayuki and Sugane, Toshio and Nakajima, Mio and Yashiro, Tomoyasu and Kagei, Kenji and Hirasawa, Naoki and Sugawara, Toshiyuki and Yamamoto, Naoyoshi and Koto, Masashi and Ezawa, Hidefumi and Kadono, Kennosuke and Tsujii, Hirohiko and Mizoe, Junetsu and Yoshikawa, Kyosan and Kandatsu, Susumu and Fujisawa, Takehiko and 宮本 忠昭 and 馬場 雅行 and 須金 紀雄 and 中嶋 美緒 and 矢代 智康 and 影井 兼司 and 平澤 直樹 and 菅原 俊幸 and 山本 直敬 and 小藤 昌志 and 江澤 英史 and 上遠野 賢之助 and 辻井 博彦 and 溝江 純悦 and 吉川 京燦 and 神立 進},
 issue = {10},
 journal = {Journal of Thoracic Oncology},
 month = {Oct},
 note = {Background:A phase I/II study was first conducted for the treatment of stage I non-small cell lung cancer(NSCLC)from 1994 to 1999 to determine the optimal dose.On the basis on the results,a phase II study using a regimen of four fractions during 1 week was performed.The purpose of the present study was to determine the local control and 5-year survival rates.
Methods:From December 2000 to November 2003,79 patients with 80 primary lesions were treated. Using a fixed dose of 52.8 GyE for stage IA NSCLC and 60.0 GyE for stage IB NSCLC in four fractions during 1 week,the primary tumors were irradiated with carbon beams alone.The average age of the patients was 74.8 years.Sixty-two(78.5%)of these patients were medically inoperable.Local control and survival were determined using the Kaplan-Meier method.The data were statistically processed using the log-rank test.
Results:All patients were observed for a minimum of 3 years or until death,with a median follow-up time of 38.6 months,ranging from 2.5 to 72.2 months.The local control rate for all patients was 90%(T1:98%,T2:80%).The patients'5-year lung cancer-specific survival rate was 68%(IA:87%,IB:42%).The overall survival was 45%(IA:62%,IB:25%).Harf of the deaths were attributable to intercurrent diseases.No toxic reactions in the lung greater than grade 3 were detected.
Conclusion:Carbon ion beam radiotherapy with a regimen of four fractions during 1 week has been proven as a valid alternative to surgery for stage INCLC and to offer particular benefits,especially for elderly and inoperable patients.},
 pages = {916--926},
 title = {Carbon Ion Radiotherapy for Stage I Non-small Cell Lung Cancer Using a Regimen of Four Fractions during 1 Week},
 volume = {2},
 year = {2007}
}