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We then compared the dosimetric data of the 8 patients developed \u003e= grade 2 RP with those of 72 patients developed \u003c= grade 1 RP. Dosimetric factors useful for predicting RP in XRT, such as the percentage of the computed tomography-defined total lung volume receiving \u003e 5, \u003e 20, and \u003e 30 GyE, and mean lung dose, were not predictive factors for RP after CRT. The dosimetric factors used for XRT are not applicable for CRT in patients with NSCLC. 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Dosimetric Factors Used for Thoracic X-Ray Radiotherapy are not Predictive of the Occurrence of Radiation Pneumonitis after Carbon-Ion Radiotherapy
https://repo.qst.go.jp/records/45142
https://repo.qst.go.jp/records/4514247f66d43-d327-441f-bda3-c37138c60031
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-04-25 | |||||
タイトル | ||||||
タイトル | Dosimetric Factors Used for Thoracic X-Ray Radiotherapy are not Predictive of the Occurrence of Radiation Pneumonitis after Carbon-Ion Radiotherapy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Koto, Masashi
× Koto, Masashi× Tsujii, Hirohiko× Yamamoto, Naoyoshi× Nishimura, Hideki× Yamada, Syougo× Miyamoto, Tadaaki× 小藤 昌志× 辻井 博彦× 山本 直敬× 山田 章吾× 宮本 忠昭 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Radiation pneumonitis (RP) is one of the most commondose-limiting toxicities in thoracic X-ray radiotherapy (XRT). Dosimetric factors are used for prediction of the occurrence of RP after XRT. Carbon-ion radiotherapy (CRT) is a promising modality because of its excellent dose localization and high biological effect on tumors. This study aims to analyze the relationship between dosimetric factors developed for XRT and the incidence of RP in patients with stage I non-small cell lung cancer (NSCLC) after CRT. We examined 80 inoperable patients with NSCLC. The ranges of the daily fraction sizes and the total doses were from 3.3 to 8.8 GyE and from 59.4 to 95.4 GyE, respectively. These doses were successfully delivered with acceptable toxicity; >=grade 2 RP was observed in 8 patients (10%). The severity of RP was graded within 6 months of the initiation of CRT using the Radiation Therapy Oncology Group criteria. These results indicate the excellent dose distribution of CRT. We then compared the dosimetric data of the 8 patients developed >= grade 2 RP with those of 72 patients developed <= grade 1 RP. Dosimetric factors useful for predicting RP in XRT, such as the percentage of the computed tomography-defined total lung volume receiving > 5, > 20, and > 30 GyE, and mean lung dose, were not predictive factors for RP after CRT. The dosimetric factors used for XRT are not applicable for CRT in patients with NSCLC. The dosimetric factors for CRT remain to be developed. - non-small cell lung cancer; carbon-ion radio-therapy; radiation pneumonitis ; dosimetric factor; normal tissue |
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書誌情報 |
The Tohoku Journal of Experimental Medicine 巻 213, 号 2, p. 149-156, 発行日 2007-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-8727 |