@article{oai:repo.qst.go.jp:00045142,
 author = {Koto, Masashi and Tsujii, Hirohiko and Yamamoto, Naoyoshi and Nishimura, Hideki and Yamada, Syougo and Miyamoto, Tadaaki and 小藤 昌志 and 辻井 博彦 and 山本 直敬 and 山田 章吾 and 宮本 忠昭},
 issue = {2},
 journal = {The Tohoku Journal of Experimental Medicine},
 month = {Oct},
 note = {Radiation pneumonitis (RP) is one of the most commondose-limiting toxicities in thoracic X-ray radiotherapy (XRT). Dosimetric factors are used for prediction of the occurrence of RP after XRT. Carbon-ion radiotherapy (CRT) is a promising modality because of its excellent dose localization and high biological effect on tumors. This study aims to analyze the relationship between dosimetric factors developed for XRT and the incidence of RP in patients with stage I non-small cell lung cancer (NSCLC) after CRT. We examined 80 inoperable patients with NSCLC. The ranges of the daily fraction sizes and the total doses were from 3.3 to 8.8 GyE and from 59.4 to 95.4 GyE, respectively. These doses were successfully delivered with acceptable toxicity; >=grade 2 RP was observed in 8 patients (10%). The severity of RP was graded within 6 months of the initiation of CRT using the Radiation Therapy Oncology Group criteria.
These results indicate the excellent dose distribution of CRT. We then compared the dosimetric data of the 8 patients developed >= grade 2 RP with those of 72 patients developed <= grade 1 RP. Dosimetric factors useful for predicting RP in XRT, such as the percentage of the computed tomography-defined total lung volume receiving > 5, > 20, and > 30 GyE, and mean lung dose, were not predictive factors for RP after CRT. The dosimetric factors used for XRT are not applicable for CRT in patients with NSCLC. The dosimetric factors for CRT remain to be developed.  - non-small cell lung cancer; carbon-ion radio-therapy; radiation pneumonitis ; dosimetric factor; normal tissue},
 pages = {149--156},
 title = {Dosimetric Factors Used for Thoracic X-Ray Radiotherapy are not Predictive of the Occurrence of Radiation Pneumonitis after Carbon-Ion Radiotherapy},
 volume = {213},
 year = {2007}
}