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Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol
https://repo.qst.go.jp/records/45104
https://repo.qst.go.jp/records/45104f5c7422f-3455-444d-b091-5f19089fe9bb
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-03-04 | |||||
| タイトル | ||||||
| タイトル | Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukuhara, Kiyoshi
× Fukuhara, Kiyoshi× Nakanishi, Ikuo× Matsumura, Tomohiro× Ozawa, Toshihiko× Miyata, Naoki× Saito, Shinichi× Ikota, Nobuo× Okuda, Haruhiro× et.al× 中西 郁夫× 小澤 俊彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural phytoalexin with various biological activities including inhibition of lipid peroxidation and free radical scavenging properties. In addition to its beneficial effects, resveratrol also has significant genotoxicity that leads to a high frequency of chromosome aberration together with micronucleus and sister chromatid exchanges. To enhance the radical scavenging activities and to reduce the genotoxicity of resveratrol, we designed 4'-methyl resveratroll analogues where a methyl group was introduced at the ortho position relative to the 4'-hydroxy group, which is responsible for both antioxidative activities and genotoxicity of resveratrol. These synthesized methyl analogues of resveratrol showed increased antioxidative activities against galvinoxyl radical as an oxyl radical species. Furthermore, the methyl analogues also surprisingly showed reduced in vitro genotoxicities, suggesting that methyl substitution may improve resveratrol efficacy. | |||||
| 書誌情報 |
Chemical Research in Toxicology 巻 21, 号 2, p. 282-287, 発行日 2008-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0893-228X | |||||
