{"created":"2023-05-15T14:34:53.106009+00:00","id":45104,"links":{},"metadata":{"_buckets":{"deposit":"34b4e0cd-8c83-4bca-9121-86b619cca78b"},"_deposit":{"created_by":1,"id":"45104","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45104"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045104","sets":["1"]},"author_link":["447904","447901","447906","447910","447909","447908","447907","447911","447902","447905","447903"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"287","bibliographicPageStart":"282","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Chemical Research in Toxicology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural phytoalexin with various biological activities including inhibition of lipid peroxidation and free radical scavenging properties.  In addition to its beneficial effects, resveratrol also has significant genotoxicity that leads to a high frequency of chromosome aberration together with micronucleus and sister chromatid exchanges.  To enhance the radical scavenging activities and to reduce the genotoxicity of resveratrol, we designed 4'-methyl resveratroll analogues where a methyl group was introduced at the ortho position relative to the 4'-hydroxy group, which is responsible for both antioxidative activities and genotoxicity of resveratrol.  These synthesized methyl analogues of resveratrol showed increased antioxidative activities against galvinoxyl radical as an oxyl radical species.  Furthermore, the methyl analogues also surprisingly showed reduced in vitro genotoxicities, suggesting that methyl substitution may improve resveratrol efficacy.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0893-228X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fukuhara, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"447901","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"447902","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumura, Tomohiro"}],"nameIdentifiers":[{"nameIdentifier":"447903","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozawa, Toshihiko"}],"nameIdentifiers":[{"nameIdentifier":"447904","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyata, Naoki"}],"nameIdentifiers":[{"nameIdentifier":"447905","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Shinichi"}],"nameIdentifiers":[{"nameIdentifier":"447906","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikota, Nobuo"}],"nameIdentifiers":[{"nameIdentifier":"447907","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okuda, Haruhiro"}],"nameIdentifiers":[{"nameIdentifier":"447908","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"447909","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"447910","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小澤 俊彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"447911","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-03-04"},"publish_date":"2008-03-04","publish_status":"0","recid":"45104","relation_version_is_last":true,"title":["Effect of Methyl Substitution on Antioxidative Property and Genotoxicity of Resveratrol"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:07:38.910026+00:00"}